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首页> 外文期刊>Tropical Animal Health and Production >Alterations in oxidant/antioxidant balance, high-mobility group box 1 protein and acute phase response in cross-bred suckling piglets suffering from rotaviral enteritis
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Alterations in oxidant/antioxidant balance, high-mobility group box 1 protein and acute phase response in cross-bred suckling piglets suffering from rotaviral enteritis

机译：患有轮状病毒肠炎的杂交乳猪的氧化剂/抗氧化剂平衡，高迁移率族box 1蛋白和急性期反应的变化

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摘要

Rotaviral enteritis has emerged as a major cause of morbidity and mortality in piglets during their post-natal life. The present study was carried out to examine high-mobility group box 1 (HMGB1) protein, acute phase response and oxidative stress indices in the serum of suckling piglets suffering from enteritis with or without association of porcine group A rotavirus infection. The present investigation utilized 23 clinical cases with signs of acute enteritis and 12 more healthy piglets of a similar age group as control animals. Out of 23 enteritis cases, 12 cases were found to be positive for porcine group A rotavirus infection as confirmed by reverse transcription-polymerase chain reaction (RT-PCR) using specific primers for group A rotavirus, and the rest were found negative. The acute enteritis cases in piglets were associated with an elevated level of HMGB1 protein and serum haptoglobin and ceruloplasmin suggestive of an acute phase response. Among the oxidative stress indices, the concentrations of malondialdehyde (MDA) and nitric oxide (NO) in serum were significantly increased. A pronounced drop of total antioxidant capacity and the activity of antioxidant enzymes such as catalase and superoxide dismutase in the serum of piglets suffering from acute enteritis compared to healthy ones were also noticed. The alterations in HMGB1 protein, acute phase response and oxidative stress indices were more pronounced in cases with the involvement of porcine rotavirus as compared to rotavirus-negative cases. It is concluded that HMGB1 protein, markers of oxidative stress and acute phase proteins might play an important role in the aetiopathogenesis of porcine diarrhoea caused by rotavirus and might be true markers in diagnosing the conditions leading to the extension of the prompt and effective therapeutic care
机译：轮状肠炎已成为仔猪出生后发病和死亡的主要原因。本研究旨在检查患有或不伴有猪A型轮状病毒感染的乳猪患肠炎的血清中的高迁移率族盒1（HMGB1）蛋白，急性期反应和氧化应激指数。本研究利用了23例有急性肠炎体征的临床病例和12例年龄更大的健康仔猪作为对照动物。在23例肠炎病例中，发现12例猪A轮状病毒感染呈阳性，这是通过使用A轮状病毒特异性引物的逆转录聚合酶链反应（RT-PCR）证实的，其余则为阴性。仔猪的急性肠炎病例与HMGB1蛋白，血清触珠蛋白和铜蓝蛋白水平升高有关，提示存在急性期反应。在氧化应激指标中，血清中丙二醛（MDA）和一氧化氮（NO）的浓度显着增加。与健康的仔猪相比，患急性肠炎的仔猪血清中的总抗氧化剂能力和抗氧化酶活性（如过氧化氢酶和超氧化物歧化酶）也明显下降。与轮状病毒阴性病例相比，猪轮状病毒感染病例中HMGB1蛋白，急性期反应和氧化应激指数的变化更为明显。结论：HMGB1蛋白，氧化应激标志物和急性期蛋白可能在轮状病毒引起的猪腹泻的发病机制中起重要作用，并且可能是诊断导致及时有效治疗扩展的条件的真正标志物

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