New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia.

Longeon A; Copp BR; Roue M; Dubois J; Valentin A; Petek S; Debitus C; Bourguet Kondracki ML

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New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia.

机译：Xestospongia属的南太平洋海洋海绵中的新生物活性卤代醌衍生物。

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Bioassay-directed fractionation of South Pacific marine sponges of the genus Xestospongia has led to the isolation of a number of halenaquinone-type polyketides, including two new derivatives named xestosaprol C methylacetal 7 and orhalquinone 8. Chemical characterization of these two new compounds was achieved by extensive 1D and 2D NMR spectroscopic studies. Evaluation of anti-phospholipase A(2), anti-farnesyltransferase and antiplasmodial activities of this series is presented and structure/activity relationships are discussed. Orhalquinone 8 displayed a significant inhibition of both human and yeast farnesyltransferase enzymes, with IC(50) value of 0.40 microM and was a moderate growth inhibitor of Plasmodium falciparum.

机译：生物测定法指导的南太平洋海藻海绵的分离已导致分离出多种卤代对苯二酚型聚酮化合物，包括名为xestosaprol C甲基缩醛7和邻苯二酚8的两种新衍生物。这两种新化合物的化学表征通过广泛的1D和2D NMR光谱研究。评价了该系列的抗磷脂酶A（2），抗法呢基转移酶和抗血浆活性，并讨论了结构/活性关系。 Orhalquinone 8表现出对人和酵母法呢基转移酶的显着抑制，IC（50）值为0.40 microM，是恶性疟原虫的中度生长抑制剂。

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《Bioorganic and medicinal chemistry》 |2010年第16期|共6页
作者
Longeon A; Copp BR; Roue M; Dubois J; Valentin A; Petek S; Debitus C; Bourguet Kondracki ML;
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中图分类药学;生物化学;
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1. New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia. [J] . Longeon A, Copp BR, Roue M, Bioorganic and medicinal chemistry . 2010,第16期

机译：Xestospongia属的南太平洋海洋海绵中的新生物活性卤代醌衍生物。
2. Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. [J] . Oku N, Nagai K, Shindoh N, Bioorganic and Medicinal Chemistry Letters . 2004,第10期

机译：三种新的抑制组蛋白脱乙酰基酶的环糊精，来自Xestospongia属的海洋海绵。
3. HALENAQUINONE DERIVATIVES FROM TROPICAL MARINE SPONGE XESTOSPONGIA SP. [J] . Yeon-Ju Lee, Chang-Kwon Kim, Song-Kyu Park Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2012,第4期

机译：来自热带海洋海绵XESTOSPONGIA SP的哈伦喹酮衍生物。
4. Bioactive natural products from marine sponges and fungal endophytes [C] . Peter Proksch, Annika Putz, Sofia Ortlepp the Phytochemical Society of Europe meeting . 2010

机译：来自海洋海绵的生物活性天然产品和真菌内心生物
5. The bacterial communities associated with two marine sponges of the genus Xestospongia. [D] . Montalvo, Naomi F. 2011

机译：与Xestospongia属的两个海洋海绵相关的细菌群落。
6. Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp. [O] . Arlette Longeon, Brent R. Copp, Elodie Quévrain, 2011

机译：来自南太平洋海洋海绵的Rhoopaloeides odorabile和Hyrtios sp。的生物活性吲哚衍生物。
7. Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp. [O] . Longeon, Arlette, Copp, Brent R., Quévrain, Elodie, 2011

机译：来自南太平洋海洋海绵的Rhoopaloeides odorabile和Hyrtios sp。的生物活性吲哚衍生物。

New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia.

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