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首页> 外文期刊>Trends In Parasitology >Programmed cell death in unicellular parasites: a prerequisite for sustained infection?
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Programmed cell death in unicellular parasites: a prerequisite for sustained infection?

机译：单细胞寄生虫中程序性细胞死亡：持续感染的前提？

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摘要

The detection of markers typical for metazoan programmed cell death (PCD) in diverse protozoan parasites raised a debate about the evolution of PCD processes and its impact on the biology of single-celled parasites. By applying the unified criteria recently developed for metazoan cell death, the conclusion is made that cell death in protozoan parasites also occurs in a programmed fashion. Several molecules or pathways which regulate PCD in higher eukaryotes have been implicated in the death of unicellular parasites. Furthermore, we emphasize that PCD enables the regulation of parasite densities in distinct host compartments and aids in avoiding inflammatory responses, thereby facilitating a sustained infection. We therefore propose that PCD pathways might represent ideal targets to combat protozoan parasites by their own means.
机译：在多种原生动物寄生虫中典型的后生动物程序性细胞死亡（PCD）标记的检测引发了关于PCD进程的演变及其对单细胞寄生虫生物学影响的辩论。通过应用最近为后生动物死亡开发的统一标准，可以得出结论，原生动物寄生虫中的细胞死亡也以程序方式发生。调节高等真核生物中PCD的几种分子或途径与单细胞寄生虫的死亡有关。此外，我们强调PCD能够调节不同宿主区室中的寄生虫密度，并有助于避免炎症反应，从而促进持续感染。因此，我们建议PCD途径可能代表以自己的方式对抗原生动物寄生虫的理想目标。

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