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首页> 外文期刊>Veterinary Anaesthesia and Analgesia >Endothelin receptor subtype A blockade does not affect the haemodynamic recovery from haemorrhage during xenon/remifentanil or isoflurane/remifentanil anaesthesia in dogs
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Endothelin receptor subtype A blockade does not affect the haemodynamic recovery from haemorrhage during xenon/remifentanil or isoflurane/remifentanil anaesthesia in dogs

机译：内皮素A受体亚型阻滞不影响狗在氙气/瑞芬太尼或异氟烷/瑞芬太尼麻醉期间从出血中恢复的血流动力学

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摘要

To test the compensatory role of endothelin-1 when acute blood loss is superimposed on anaesthesia, by characterizing the effect of systemic endothelin receptor subtype A (ETA) blockade on the haemodynamic and hormonal responses to haemorrhage in dogs anaesthetized with xenon/remifentanil (X/R) or isoflurane/remifentanil (I/R). Prospective experimental randomized controlled study. Six female Beagle dogs, 13.4 pl 1.3 kg. Animals were anaesthetized with remifentanil 0.5 og kgp# minutep# plus either 0.8% isoflurane (I/R) or 63% xenon (X/R), with and without (Control) the systemic intravenous endothelin receptor subtype A antagonist atrasentan (four groups, n = 6 each). After 60 minutes of baseline anaesthesia, the dogs were bled (20 mL kgp#) over 5 minutes and hypovolemia was maintained for 1 hour. Continuous haemodynamic monitoring was performed via femoral and pulmonary artery catheters; vasoactive hormones were measured before and after haemorrhage. In Controls, systemic vascular resistance (SVR), vasopressin and catecholamine plasma concentrations were higher with X/R than with I/R anaesthesia at pre-haemorrhage baseline. The peak increase after haemorrhage was higher during X/R than during I/R anaesthesia (SVR 7420 pl 867 versus 5423 pl 547 dyne seconds cme; vasopressin 104 pl 23 versus 44 pl 6 pg mLp#; epinephrine 2956 pl 310 versus 177 pl 99 pg mLp#; norepinephrine 862 pl 117 versus 195 pl 33 pg mLp#, p < 0.05). Haemorrhage reduced central venous pressure from 3 pl 1 to 1 pl 1 cmHO (I/R, ns) and from 8 pl 1 to 5 pl 1 cmHO (X/R, p < 0.05), but did not reduce mean arterial pressure, nor cardiac output. Atrasentan did not alter the haemodynamic and hormonal response to haemorrhage during either anaesthetic protocol. Selective ETA receptor blockade with atrasentan did not impair the haemodynamic and hormonal compensation of acute haemorrhage during X/R or I/R anaesthesia in dogs.
机译：通过表征全身性内皮素A受体亚型（ETA）阻断对氙气/瑞芬太尼（X / R）或异氟烷/瑞芬太尼（I / R）。前瞻性实验随机对照研究。六只雌性Beagle犬，重13.4磅1.3公斤。用0.5毫克/升/分钟的瑞芬太尼加0.8％的异氟烷​​（I / R）或63％的氙气（X / R）麻醉动物，有和没有（对照）全身性静脉内皮素受体亚型A拮抗剂阿曲生坦（四组， n = 6）。基线麻醉60分钟后，在5分钟内给狗放血（20 mL kgp＃），并维持血容量不足1小时。通过股动脉和肺动脉导管进行连续血流动力学监测;出血前后测量血管活性激素。在对照中，出血前基线时，X / R的全身血管阻力（SVR），血管加压素和儿茶酚胺血浆浓度高于I / R麻醉。 X / R期间出血后的峰值增加高于I / R麻醉期间（SVR 7420 pl 867与5423 pl 547达因秒cme;加压素104 pl 23对44 pl 6 pg mLp＃;肾上腺素2956 pl 310对177 pl 99 pg mLp＃;去甲肾上腺素862 pl 117与195 pl 33 pg mLp＃，p <0.05）。出血使中心静脉压从3 pl 1降低到1 pl 1 cmHO（I / R，ns），从8 pl 1降低到5 pl 1 cmHO（X / R，p <0.05），但没有降低平均动脉压，也没有降低心输出量。在两种麻醉方案中，阿曲生坦均未改变对出血的血流动力学和激素反应。用阿曲生坦选择性阻断ETA受体不会损害狗X / R或I / R麻醉期间急性出血的血流动力学和激素补偿。

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