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首页> 外文期刊>Veterinary Dermatology >Epidemiology, clinical signs, histopathology and molecular characterization of canine leproid granuloma: a retrospective study of cases from Brazil.
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Epidemiology, clinical signs, histopathology and molecular characterization of canine leproid granuloma: a retrospective study of cases from Brazil.

机译：犬类麻风肉芽肿的流行病学，临床体征，组织病理学和分子特征：对巴西病例的回顾性研究。

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Thirty-eight cases of canine leproid granuloma were diagnosed between 2000 and 2008. Diagnosis was based upon clinical and histopathological findings and the presence of acid-fast bacilli in skin sections. The clinical lesions were localized predominantly on the pinnae and included papules, plaques and nodules, with or without ulceration. Boxer dogs were the breed most affected. Histopathological findings included nodular to diffuse pyogranulomatous, lymphoplasmocytic inflammatory infiltrates, with or without necrosis, localized in the dermis or subcutaneous tissue. The bacillary loading and morphology were variable among the lesions analysed. There was no significant correlation between bacterial load and histopathological pattern, dominant type of inflammatory infiltration or the amount of necrosis or giant cells. No correlation was observed between giant cells and histopathological pattern. In the majority of cases where a PCR-based assay was done, a novel mycobacterium species as the main aetiological agent was identified, as reported in previous studies.Digital Object Identifier http://dx.doi.org/10.1111/j.1365-3164.2010.00934.x
机译：在2000年至2008年之间，诊断出38例犬类麻风肉芽肿病例。诊断基于临床和组织病理学发现以及皮肤切片中存在耐酸杆菌。临床病变主要集中在耳廓上，包括丘疹，斑块和结节，有或没有溃疡。拳师犬是受影响最大的品种。组织病理学发现包括位于真皮或皮下组织的结节性弥漫性脓性肉芽肿性，浆细胞性炎性浸润，伴或不伴坏死。细菌负荷和形态在所分析的病变之间是可变的。细菌载量与组织病理学模式，炎症浸润的主要类型或坏死或巨细胞的数量之间无显着相关性。在巨细胞和组织病理学模式之间未观察到相关性。如以前的研究报道，在大多数基于PCR的检测中，鉴定出一种新的分枝杆菌作为主要病原体。数字对象标识符http://dx.doi.org/10.1111/j.1365 -3164.2010.00934.x

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