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首页> 外文期刊>Viral immunology >Effects of Risk Factors on Anti-HBs Development in Hepatitis B Vaccinated and Nonvaccinated Populations
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Effects of Risk Factors on Anti-HBs Development in Hepatitis B Vaccinated and Nonvaccinated Populations

机译：危险因素对乙肝疫苗接种人群和非疫苗接种人群抗HBs发生的影响

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Hepatitis B infection is still a major global health problem even though safe and effective vaccines have been available for more than 30 years. Although development of protective antibody to hepatitis B surface antigen (anti-HBs) is a common phenomenon after vaccination as well as natural infection, sometimes it does not appear even after complete vaccination. In the present study, whether the impairment of the development of anti-HBs in naturally infected and/or vaccinated populations is associated with immunomodulating risk factors (i.e., age, gender, smoking, and diabetes) and/or other risk factors (i.e., socioeconomic status, dental, and saloon exposure) was investigated through a cross-sectional study. Among 204 nonvaccinated patients, 132 (64.7%) tested positive for anti-HBc, indicating that they had been exposed to hepatitis B virus (HBV) at least once in their lifetime. Exposure to HBV (anti-HBc positive) was significantly higher among low-income people, dental exposed, and saloon users. Among anti-HBc positive patients, only 44 (33.3%) developed natural immunity with anti-HBs. Impairment in anti-HBs formation was found to be significantly high among cigarette smokers. However, no significant association of anti-HBs development was observed with age, gender, socioeconomic status, diabetes, dental exposure, and using saloon. Consistently, the frequency of developing protective anti-HBs (>= 10 IU/L) among a vaccinated population was almost nine times less among smokers. These data suggest that anti-HBs development, either naturally or after vaccination, is significantly lower among smokers. It emphasizes the need to check the anti-HBs status in smokers after vaccination, and a booster vaccination should be administered if the anti-HBs antibody titer decreases below the protective level.
机译：尽管安全有效的疫苗已经使用了30多年，但乙型肝炎感染仍然是全球主要的健康问题。尽管针对乙肝表面抗原（抗HBs）的保护性抗体的开发是疫苗接种以及自然感染后的常见现象，但有时甚至在完全疫苗接种后也不会出现。在本研究中，自然感染和/或接种疫苗的人群中抗HBs的发育障碍是否与免疫调节危险因素（即年龄，性别，吸烟和糖尿病）和/或其他危险因素（即社会经济状况，牙科和四门轿车的暴露）通过一项横断面研究进行了调查。在204名未接种疫苗的患者中，有132名（64.7％）的抗HBc检测呈阳性，表明他们一生中至少接触过一次乙型肝炎病毒（HBV）。在低收入人群，牙齿暴露者和四门轿车使用者中，HBV暴露（抗HBc阳性）显着更高。在抗HBc阳性患者中，只有44（33.3％）位患者对抗HBs具有天然免疫力。发现吸烟者中抗HBs形成的损害明显很高。但是，未观察到抗HBs的发展与年龄，性别，社会经济状况，糖尿病，牙齿暴露和使用轿车的相关性。一致地，在接种疫苗的人群中，产生保护性抗HBs（> = 10 IU / L）的频率几乎比吸烟者少9倍。这些数据表明，无论是自然的还是接种疫苗后，吸烟者的抗HBs发生率均显着降低。它强调需要在接种疫苗后检查吸烟者中的抗HBs状况，如果抗HBs抗体滴度降至保护水平以下，则应加强接种。

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