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首页> 外文期刊>Virchows Archiv: an international journal of pathology >Epidermal growth factor receptor is a marker for syncytiotrophoblastic cells in testicular germ cell tumors.
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Epidermal growth factor receptor is a marker for syncytiotrophoblastic cells in testicular germ cell tumors.

机译：表皮生长因子受体是睾丸生殖细胞肿瘤中合体滋养细胞的标志物。

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摘要

The epidermal growth factor receptor (EGFR) has been implicated in the pathogenesis, therapy and prognosis of various tumor types. The aim of this study was to investigate EGFR expression in a large series of testicular germ cell tumors (TGCTs). A total of 88 TGCTs (37 of pure type and 51 of mixed type) comprising a total of 44 seminoma, 49 embryonal carcinoma, 32 yolk sac tumor, 28 teratoma and 7 choriocarcinoma components were immunostained for EGFR. EGFR reactivity was observed in the stromal cells of embryonal carcinoma (29%) and in epithelial compartments of teratoma (71%). In addition, EGFR staining was consistently detected in syncytiotrophoblastic cells of choriocarcinoma, seminoma, embryonal carcinoma and yolk sac tumor components. EGFR staining, similar to beta-human chorionic gonadotropin (HCG) immunohistochemistry, was efficiently able to identify syncytiotrophoblastic cells in TGCTs. This study shows that EGFR is expressed in a subset of testicular germ cell tumors and suggests that EGFR may be a useful marker for syncytiotrophoblastic cells.
机译：表皮生长因子受体（EGFR）已与多种肿瘤类型的发病机理，治疗和预后有关。这项研究的目的是研究在一系列睾丸生殖细胞肿瘤（TGCT）中的EGFR表达。用EGFR免疫染色了总共88份TGCT（纯型37份，混合型51份），包括44例精原细胞瘤，49例胚胎癌，32例卵黄囊瘤，28例畸胎瘤和7例绒癌。在胚胎癌的基质细胞（29％）和畸胎瘤的上皮区室（71％）中观察到EGFR反应性。另外，在绒癌，精原细胞瘤，胚胎癌和卵黄囊肿瘤成分的合体滋养层细胞中始终检测到EGFR染色。 EGFR染色类似于β-人绒毛膜促性腺激素（HCG）免疫组织化学，能够有效地鉴定TGCT中的合体滋养层细胞。这项研究表明，EGFR在睾丸生殖细胞肿瘤的一部分中表达，并提示EGFR可能是合体滋养层细胞的有用标记。

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