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首页> 外文期刊>Virchows Archiv: an international journal of pathology >Poor prognosis of uterine serous carcinoma compared with grade 3 endometrioid carcinoma in early stage patients.
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Poor prognosis of uterine serous carcinoma compared with grade 3 endometrioid carcinoma in early stage patients.

机译：与早期阶段的3级子宫内膜样癌相比，子宫浆液性癌预后较差。

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Difference in prognosis between grade 3 endometrioid carcinoma (G3EC) of the endometrium and uterine serous carcinoma (USC) is controversial. In this study, we further evaluated the difference in prognosis, if any, between G3EC (n?=?61) and USC (n?=?47) on a total of 565 patients with endometrial cancer. In addition, meta-analysis was performed using data from seven previous publications (n?=?8,637) and from the Asan Medical Center (n?=?108). Regarding the cases from our institution, USC tended to occur in older patients (≥65 years) than G3EC (P?=?0.011). Deep myometrial invasion (more than or equal to half) was more frequently identified in G3EC (36/61, 59.0 %) than in USC (17/47, 36.2 %) (P?=?0.021). Between patients with early stage G3EC and USC (stages I and II), there were no significant differences in any clinicopathological parameter, but there was a significant difference in overall survival (P?=?0.017) that was not found in advanced stage (P?=?0.588). USC was an independent prognostic factor for poor overall survival (hazard ratio, 6.125; P?=?0.030) in early stage patients. In the meta-analysis on 5-year survival in patients with early stage cancers, which also included our study results, a higher relative risk (1.92, 95 % CI 1.62-2.27) was demonstrated in USC than in G3EC (P?
机译：子宫内膜3级子宫内膜样癌（G3EC）和子宫浆液性癌（USC）之间的预后差异存在争议。在这项研究中，我们进一步评估了总共565例子宫内膜癌患者中G3EC（n？=？61）和USC（n？=？47）之间的预后差异。另外，荟萃分析是使用以前的七个出版物（n = 8637）和牙山医学中心（n = 108）的数据进行的。关于我们机构的病例，USC倾向于比G3EC的年龄更大（≥65岁）的患者发生（P = 0.011）。与USC（17/47，36.2％）相比，G3EC（36/61，59.0％）更频繁地发现深肌层浸润（大于或等于一半）（P≥0.021）。在早期G3EC和USC（I和II期）患者之间，任何临床病理参数均无显着差异，但总生存率（P≤0.017）却未达到晚期（P≥0.017）。 ？=？0.588）。 USC是早期患者总体生存不良的独立预后因素（危险比为6.125; P <= 0.030）。在包括早期研究在内的早期癌症患者5年生存率的荟萃分析中，与C3EC相比，USC的相对危险度更高（1.92，95％CI 1.62-2.27）。 0.001）。总之，我们的研究表明，与G3EC相比，USC与较差的预后相关，仅在早期癌症患者中，这表明应根据组织学类型考虑不同的治疗策略，以改善治疗效果。

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