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首页> 外文期刊>The International journal of pharmacy practice >Concurrent use of complementary and alternative medicine with antiretroviral therapy reduces adherence to HIV medications
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Concurrent use of complementary and alternative medicine with antiretroviral therapy reduces adherence to HIV medications

机译：同时使用补充药物和替代药物与抗逆转录病毒疗法会降低对HIV药物的依从性

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Objective Antiretroviral therapy requires strict adherence to ensure therapeutic success. Concurrent use of complementary and alternative medicine (CAM) could alter the adherence to and thereby effectiveness of antiretroviral drugs. This study examined the association of CAM use with adherence to antiretroviral therapy (ART) and CD4 count. Methods: The study was conducted in two HIV clinics: one in a semi-urban, the other in a rural area. Adherence to ART was assessed using the Morisky Medication Adherence Scale (MMAS). Data on type of CAM used and MMAS adherence were collected by patient interview and demographic; clinical data were collected from hospital records. Results Altogether 212 HIV patients participated in the exit study conducted over 3 months. Almost half (47.9%) used CAM concurrently with antiretroviral drugs. Dietary supplements (40.3%), healing systems (36.5%) and exercise (23.2%) were mainly used. The use of CAM significantly lowered adherence to ART (89.4% in non-CAM users versus 82.5% in CAM users, P = 0.01). Improvement in CD4 count was less in patients using CAM compared to non-CAM users although the difference was not statistically significant (310.5 ± 294.0 cells/L in CAM users versus 224.5 ± 220.0 cells/L in non-CAM users, P = 0.13). Patients attending the rural HIV clinic were more likely to use CAM compared to patients attending semi-urban hospital (χ 2 test = 7.0; P 0.01). Conclusion: Use of CAM could lower adherence to antiretroviral therapy. There is need to develop protocol which could help in monitoring CAM use in HIV patients especially those from rural settings. IJPP
机译：目的抗逆转录病毒疗法需要严格遵守以确保治疗成功。同时使用补充和替代药物（CAM）可能会改变抗逆转录病毒药物的依从性，从而改变其有效性。这项研究检查了CAM使用与坚持抗逆转录病毒疗法（ART）和CD4计数之间的关系。方法：该研究是在两家艾滋病诊所进行的：一家在半城市，另一家在农村。使用Morisky药物依从性量表（MMAS）评估对ART的依从性。通过患者访谈和人口统计学收集了使用的CAM类型和MMAS依从性的数据。从医院记录中收集临床数据。结果总共有212名HIV患者参加了为期3个月的退出研究。几乎一半（47.9％）的人同时使用CAM和抗逆转录病毒药物。主要使用膳食补充剂（40.3％），康复系统（36.5％）和运动（23.2％）。 CAM的使用显着降低了对ART的依从性（非CAM用户为89.4％，而CAM用户为82.5％，P = 0.01）。与非CAM用户相比，使用CAM的患者CD4计数的改善较少，尽管差异无统计学意义（CAM用户为310.5±294.0细胞/ L，非CAM用户为224.5±220.0细胞/ L，P = 0.13） 。与在半城市医院就诊的患者相比，在农村HIV诊所就诊的患者更可能使用CAM（χ2检验= 7.0; P <0.01）。结论：使用CAM可能降低抗逆转录病毒疗法的依从性。需要开发协议，以帮助监测艾滋病毒患者，尤其是农村地区的艾滋病患者中的CAM使用情况。联合会

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