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首页> 外文期刊>The International journal of pharmacy practice >A randomised comparison of methadone against buprenorphine in the treatment of opioid dependency: a feasibility study
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A randomised comparison of methadone against buprenorphine in the treatment of opioid dependency: a feasibility study

机译：美沙酮与丁丙诺啡在阿片类药物依赖治疗中的随机比较：一项可行性研究

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Methadone is the main opiate substitute drug prescribed in Scotland.Buprenorphine has been proposed as an alternative in the treatment of opiate dependency. It has higher unit costs but may have additional benefits. It is difficult to overdose on buprenorphine alone and it has the ability to block the effects of other opiates.Administration of buprenorphine can take place three times weekly, thereby reducing pharmacy workload associated with supervised consumption. Buprenorphine is gradually being prescribed within clinic and community treatment contexts, despite little evidence of clinical and cost-effectiveness in these settings.To prescribe and administer buprenorphine requires different skills from doctors and pharmacists There is no direct equivalent dose of methdaone and buprenorphine, and buprenorphine is administered as a sublingual tablet which makes supervised consumption complex. A small randomised controlled trial was conducted to test the methods (recruitment, randomisation, and acceptability) to be used in a larger definitive study.
机译：美沙酮是苏格兰处方的主要鸦片替代药物。丁丙诺啡已被提议作为鸦片依赖性治疗的替代药物。它具有较高的单位成本，但可能会有其他好处。单独使用丁丙诺啡很难过量，并且具有阻断其他阿片类药物的作用的能力。丁丙诺啡每周可进行3次给药，从而减少了与监督消费有关的药房工作量。尽管很少有证据表明丁丙诺啡在临床和社区中具有临床和成本效益，但丁丙诺啡正在临床和社区治疗范围内逐步开处方。开处方和施用丁丙诺啡需要与医生和药剂师不同的技能没有直接等效剂量的美甲酮，丁丙诺啡和丁丙诺啡以舌下片剂形式给药，这使得监督性消费变得复杂。进行了一项小型的随机对照试验，以测试用于较大的确定性研究中的方法（招募，随机化和可接受性）。

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