Primal structure and activity studies of allatostatin 4 (AST 4)

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Primal structure and activity studies of allatostatin 4 (AST 4)

机译：阿托他汀4（AST 4）的原始结构和活性研究

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The juvenile hormones (JH) are critical to the control of insect development and reproduction. The production of JH by the corpora allata (CA) is regulated in part by peptides originating from brain. One group of these peptides termed allatostatins (AST) reversibly inhibits the biosynthesis of JH invitro. The correlation of these events suggests that AST, i.e. their biosynthesis, are important in the regulation of JH biosynthesis. The D. punctata was maintained and staged females were obtained. Analogs were synthesized by tBoc solid phase peptide synthesis. Each analog was purified by HPLC, and amino acid composition and peptide quantity were determined by amino acid analysis. The radiochemical in vitro CA, i. e. JH biosynthesis assay was used to test the relation of structure and activity.

机译：少年激素（JH）对于控制昆虫的发育和繁殖至关重要。体集（CA）产生的JH部分受源自大脑的肽的调节。这些肽中的一组被称为allatostatin（AST）可逆地抑制JH的生物合成。这些事件的相关性表明，AST，即它们的生物合成，在调节JH生物合成中很重要。维持点状D. punctata并获得分期雌性。通过tBoc固相肽合成法合成类似物。通过HPLC纯化每种类似物，并通过氨基酸分析确定氨基酸组成和肽量。放射化学体外CA，i。 e。 JH生物合成测定法用于测试结构和活性之间的关系。

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《Chinese science bulletin》 |1995年第8期|共2页
作者
GUAN Xuechen;
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正文语种 eng
中图分类自然科学现状及发展;
关键词
corpora allata (CA); juvenile hormone (JH); allatostatin (AST); cockroach Diploptera punctata;

机译：已携带尸体（CA）;少年激素（JH）;阿托他汀（AST）;蟑螂斑点双翅目;

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1. Primal structure and activity studies of allatostatin 4 (AST 4) [J] . GUAN Xuechen Chinese science bulletin . 1995,第8期

机译：阿托他汀4（AST 4）的原始结构和活性研究
2. Structure-activity studies with endogenous allatostatins from Periplaneta americana: Expressed receptor compared with functional bioassay. [J] . Gade G, Marco HG, Richter D, Journal of Insect Physiology . 2008,第6期

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3. Synthesis, Biological Activity, and Hologram Quantitative Structure-Activity Relationships of Novel Allatostatin Analogues [J] . Zhen-peng Kai, Juan Huang, Yong Xie Journal of Agricultural and Food Chemistry . 2010,第5期

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4. Structure-Cytotoxicity/Antiviral Activity Relationship Studies of Nucleoside Analogs Using Structure-Activity Maps [C] . Ravi R. Parakulam, Mathew L. Lesniewski, Michael A. Marquis II, AAAI Symposium . 1999

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5. I. Comparison of translesion bypass of guanine-N2 monoadducts of mitomycin C and guanine -N7 monoadducts of 2,7-diaminomitosene by T7 exo-, Klenow exo-, eta and Klenow exo+ DNA polymerases. II. Structure-based design, synthesis, structure-conformation and structure -activity relationships studies of D-Phe-Pro-D-Arg-P1'-CONH2 tetrapeptides with inhibitory activity for thrombin. [D] . Clement, Cristina C. 2006

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6. Distribution of C-type allatostatin (C-AST)-like immunoreactivity in the central nervous system of the copepod Calanus finmarchicus [O] . Caroline H. Wilson, Andrew E. Christie -1

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7. Distribution of C-type allatostatin (C-AST)-like immunoreactivity in the central nervous system of the copepod Calanus finmarchicus [O] . Caroline H. Wilson, Andrew E. Christie 2010

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8. Modelling Molecular Structures for Computer-Assisted Studies of Drug Structure-Activity Relations [R] . Jerman-Blazic, B., Randic, M. 1983

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Primal structure and activity studies of allatostatin 4 (AST 4)

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