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首页> 外文期刊>Phytotherapy research: PTR >Antitumor effects of saponin extract from Patrinia villosa (Thunb.) Juss on mice bearing U14 cervical cancer
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Antitumor effects of saponin extract from Patrinia villosa (Thunb.) Juss on mice bearing U14 cervical cancer

机译：绒毛败酱中的皂苷提取物对患有U14宫颈癌的小鼠的抗肿瘤作用

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摘要

Saponin extracted from Patrinia villosa (Thunb.) Juss (SPVJ) is a Chinese medicine which is used widely by traditional medicine doctors. In this study, the antitumor effects and the possible mechanisms of SPVJ were investigated in mice bearing U14 cervical cancer. The results showed that SPVJ (50 mg/kg and 100 mg/kg) effectively reduced the weight of U14 cervical tumor (35.1% and 57.1%, respectively). Compared with the control group, SPVJ (100 mg/kg) significantly increased tumor cells in the G0/G1 phase (38.1% vs 68.5%), increased the number of cells in apoptosis (9.4% vs 28.9%) and G0/G1 phase and decreased the number of cells in S phase (41% vs 26.2%) and G2/M (20.9% vs 5.3%), inhibited proliferating cell nuclear antigen (PCNA) of tumor cell (80.6% vs 21.8%), decreased the expression of mutant p53 (66.4% vs 33.5%) and bcl-2 protein (78.2% vs 20.3%). The mechanism of the SPVJ antitumor effect might be associated with inhibition of tumor cells in G0/G1 phase, inducing: apoptosis and inhibiting the expression of PCNA, mutant P53 and Bcl-2 protein. Copyright (C) 2008 John Wiley & Sons, Ltd.
机译：从绒毛败酱（Patrinia villosa）提取的皂苷是一种中药，被传统医学医生广泛使用。在这项研究中，SPVJ的抗肿瘤作用及其可能的机制在携带U14宫颈癌的小鼠中进行了研究。结果表明，SPVJ（50 mg / kg和100 mg / kg）有效减轻了U14宫颈癌的重量（分别为35.1％和57.1％）。与对照组相比，SPVJ（100 mg / kg）显着增加了G0 / G1期的肿瘤细胞（38.1％vs 68.5％），增加了凋亡和G0 / G1期的细胞数量（9.4％vs 28.9％）。减少S期细胞数量（41％vs. 26.2％）和G2 / M（20.9％vs 5.3％），抑制肿瘤细胞的增殖细胞核抗原（PCNA）（80.6％vs 21.8％），降低表达突变体p53（66.4％vs 33.5％）和bcl-2蛋白（78.2％vs 20.3％）。 SPVJ的抗肿瘤作用机制可能与抑制G0 / G1期的肿瘤细胞，诱导细胞凋亡和抑制PCNA，突变体P53和Bcl-2蛋白的表达有关。版权所有（C）2008 John Wiley＆Sons，Ltd.

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