A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist: 1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo(g)quinoline-6,7-diol.

Liu D; Dijkstra D; de-Vries JB; Wikstrom HV

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A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist: 1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo(g)quinoline-6,7-diol.

机译：潜在的多巴胺D1 / D2激动剂的新型合成和药理评估：1-丙基-1,2,3,4,4a，5,10,10a-八氢苯并（g）喹啉-6,7-二醇。

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Previously, we have demonstrated that enone prodrugs of dopaminergic catecholamines represent a new type of dopamine (DA) agonist. Trans-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol (TL-334), the active form of trans-1-propyl-2,3,4,4a,5,7,8,9,10,10a-decahydro-1H-benzo[g]quinolin-6-one (GMC-6650), in vivo showed an extremely potent dopaminergic activity. Here, we report a novel synthesis and a pharmacological evaluation of TL-334 by means of microdialysis.

机译：以前，我们已经证明多巴胺能儿茶酚胺的烯酮前药代表一种新型的多巴胺（DA）激动剂。反式-1-丙基-1,2,3,4,4a，5,10,10a-八氢苯并[g]喹啉-6,7-二醇（TL-334），反式-1-丙基-2的活性形式，3,4,4a，5,7,8,9,10,10a-十氢-1H-苯并[g]喹啉-6-一（GMC-6650），在体内表现出极强的多巴胺能活性。在这里，我们报告通过微透析的TL-334的新型合成和药理评价。

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《Bioorganic and medicinal chemistry》 |2008年第6期|共7页
作者
Liu D; Dijkstra D; de-Vries JB; Wikstrom HV;
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正文语种 eng
中图分类药学;生物化学;
关键词
g lt; 3gt; 4a; novel; Evaluation; pharmacological;

机译：g 3;4a;新颖;评价;药理学;

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1. A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist: 1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo(g)quinoline-6,7-diol. [J] . Liu D, Dijkstra D, de-Vries JB, Bioorganic and medicinal chemistry . 2008,第6期

机译：潜在的多巴胺D1 / D2激动剂的新型合成和药理评估：1-丙基-1,2,3,4,4a，5,10,10a-八氢苯并（g）喹啉-6,7-二醇。
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A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist: 1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo(g)quinoline-6,7-diol.

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