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首页> 外文期刊>Hepato-gastroenterology. >Macroscopic types of intrahepatic cholangiocarcinoma: clinicopathologic features and surgical outcomes.
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Macroscopic types of intrahepatic cholangiocarcinoma: clinicopathologic features and surgical outcomes.

机译：肝内胆管癌的宏观类型：临床病理特征和手术结局。

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BACKGROUND/AIMS: The prognosis of patients with intrahepatic cholangiocarcinoma is different for the different macroscopic types of this tumor. This study correlated clinicopathologic features and outcome after surgery with macroscopic types of intrahepatic cholangiocarcinoma to determine prognostic predictors. METHODOLOGY: Resected intrahepatic cholangiocarcinomas were classified into the following growth types: mass-forming (n = 10), periductal-infiltrating (n = 11), mass-forming plus periductal-infiltrating (n = 14), and intraductal (n = 2). Intraductal tumors were not considered further. The prognostic significance of clinicopathologic features was determined by univariate and multivariate analyses. RESULTS: Perineural invasion (P = 0.00051), lymphatic invasion (P = 0.0088), and positive resection margin (P = 0.028) were less frequent in patients with mass-forming tumors than with mass-forming plus periductal-infiltrating tumors. Patients with mass-forming plus periductal-infiltrating tumors had shorter survival than those with mass-forming tumors (P = 0.0072). By univariate analysis, an elevated serum carcinoembryonic antigen concentration, lymphatic invasion, lymph node metastasis, intrahepatic metastasis, and positive resection margin predicted shorter survival after surgery. An elevated serum carcinoembryonic antigen concentration, lymphatic invasion, and positive resection margin were independent prognostic factors on multivariate analysis. The macroscopic type did not correlate independently with prognosis. CONCLUSIONS: Extended hepatic resection should be performed in patients with intrahepatic cholangiocarcinoma to obtain a tumor-free margin of resection.
机译：背景/目的：肝内胆管癌患者的预后因该肿瘤的不同宏观类型而异。这项研究将宏观病理类型的肝内胆管癌与手术后的临床病理特征和预后相关联，以确定预后指标。方法：切除的肝内胆管癌分为以下生长类型：肿块形成（n = 10），导管周围浸润（n = 11），肿块形成加导管周围浸润（n = 14）和导管内（n = 2） ）。导管内肿瘤不再被考虑。通过单因素和多因素分析确定临床病理特征的预后意义。结果：肿块形成性肿瘤患者的神经周围浸润（P = 0.00051），淋巴管浸润（P = 0.0088）和切除切缘阳性（P = 0.028）比肿块形成性和导管周围浸润性肿瘤的发生率低。伴有肿块形成和导管周围浸润的肿瘤患者的生存期短于伴有肿块形成的肿瘤（P = 0.0072）。通过单因素分析，血清癌胚抗原浓度升高，淋巴管浸润，淋巴结转移，肝内转移和阳性切除余量预示手术后生存期缩短。多因素分析显示，血清癌胚抗原浓度升高，淋巴管浸润和切除切缘阳性是独立的预后因素。宏观类型与预后无关。结论：肝内胆管癌患者应行扩大肝切除术以达到无肿瘤切除的目的。

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