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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Human Hepatic Stellate Cells Are Liver-Resident Antigen-Presenting Cells
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Human Hepatic Stellate Cells Are Liver-Resident Antigen-Presenting Cells

机译:人肝星状细胞是常驻肝脏的抗原呈递细胞

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To the Editor: We read with great interest the article published in this journal by Schildberg et al. In this study, the investigators demonstrated -that hepatic stellate cells (HSCs) veto naive cluster of differentiation (CD) 8 T-cell priming through a cell-contact-dependent mechanism, and that this novel HSC function is dependent on their activation state. High expression levels of CD54 on HSCs correlated with impaired expression of interleukin (IL)-2 receptor and IL-2 production in T cells. The take-home message of this study is the identification of a direct role of HSCs in controlling non-major histocompatibility complex (MHC)-restricted dependent immune tolerance.
机译:致编辑:我们非常感兴趣地阅读了Schildberg等人在该期刊上发表的文章。在这项研究中,研究人员证明了-肝星状细胞(HSC)否决分化(CD)8 T细胞的幼稚簇是通过细胞接触依赖性机制启动的,并且这种新颖的HSC功能取决于其激活状态。 HSC上CD54的高表达水平与T细胞中白介素(IL)-2受体的表达受损和IL-2产生有关。这项研究的实际意义是鉴定HSC在控制非主要组织相容性复合体(MHC)限制的依赖性免疫耐受中的直接作用。

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