To the Editor: In their commentary, Alisi et al. emphasize the function of hepatic stellate cells (HSCs) as antigen-presenting cells (APCs) besides their regulatory function. As indicated by Alisi et al., HSCs can, in principle, act as APCs for cluster of differentiation (CD)4, CD8, and natural killer T cells. It remained unclear how efficiently HSCs function as APCs relative to other hepatic cells, in particular being located in the Disse space next to liver sinusoidal endothelial cells (LSECs), a well-documented liver-resident APC.
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