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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Lack of an Association Between an Apolipoprotein C3 Genetic Variant and the Liver Fat Content in Patients with Type 2 Diabetes
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Lack of an Association Between an Apolipoprotein C3 Genetic Variant and the Liver Fat Content in Patients with Type 2 Diabetes

机译：缺乏载脂蛋白C3基因变异与2型糖尿病患者肝脂肪含量之间的关联

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To the Editor: We read with great interest the article by Kozlitina et al., who found no causal relationship between apolipoprotein C3 (APOC3) variants and hepatic triglyceride contents in middle-aged men and women. These results are not in accordance with a recent publication by Petersen et al., who demonstrated that C-482T and T-455C polymorphisms in APOC3 are associated with nonalcoholic fatty liver disease (NAFLD) and insulin resistance. Even though NAFLD is well known to be associated with insulin resistance and diabetes mellitus, the link between certain genetic polymorphisms, NAFLD, and insulin resistance is quite complex. Indeed, the patatin-like phospholipase domain containing 3 (PNPLA3) polymorphism is strongly associated with NAFLD' but not with obesity or insulin resistance. In contrast, Petersen et al. found that genetic variants in APOC3 are associated with the liver fat content and insulin resistance; their results, however, have not been confirmed by Kozlitina et al. We recently published a study confirming that in people with type 2 diabetes, the liver fat content was related to the rs738409 PNPLA3 polymorphism.5 In this discordant context, we set out to determine whether the liver fat content, evaluated with proton magnetic resonance spectros-copy, was associated with the rs2854l 17 APOC3 polymorphism in this population. The study involved 253 patients with type 2 diabetes. One hundred fifty-eight patients (62.4%) had steatosis (hepatic triglyceride content >5.5%). In comparison with patients without steatosis, patients with steatosis had a higher body mass index, a higher visceral fat area, higher plasma alanine aminotransferase levels, higher plasma triglyceride levels, and lower plasma adiponectin levels.
机译：致编辑：我们非常感兴趣地阅读了Kozlitina等人的文章，他们发现载脂蛋白C3（APOC3）变体与中年男女的肝甘油三酯含量之间没有因果关系。这些结果与Petersen等人的最新出版物不一致，后者证明了APOC3中的C-482T和T-455C多态性与非酒精性脂肪性肝病（NAFLD）和胰岛素抵抗有关。尽管众所周知，NAFLD与胰岛素抵抗和糖尿病有关，但某些遗传多态性，NAFLD和胰岛素抵抗之间的联系还是很复杂的。实际上，含有3（PNPLA3）多态性的patatin样磷脂酶结构域与NAFLD'密切相关，但与肥胖或胰岛素抵抗无关。相反，彼得森等。发现APOC3的遗传变异与肝脂肪含量和胰岛素抵抗有关;然而，他们的结果尚未得到Kozlitina等人的证实。我们最近发表了一项研究，证实在2型糖尿病患者中，肝脏脂肪含量与rs738409 PNPLA3多态性有关。5在这种不一致的情况下，我们着手确定是否通过质子磁共振波谱仪评估了肝脏脂肪含量，该拷贝与该人群中的rs28541 17 APOC3多态性有关。该研究涉及253名2型糖尿病患者。 158名患者（62.4％）患有脂肪变性（肝甘油三酯含量> 5.5％）。与没有脂肪变性的患者相比，患有脂肪变性的患者具有更高的体重指数，更高的内脏脂肪面积，更高的血浆丙氨酸氨基转移酶水平，更高的血浆甘油三酸酯水平和更低的血浆脂联素水平。

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