Liver and systemic insulin resistance

LanthierN.; LeclercqI.A.

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Liver and systemic insulin resistance

机译：肝和全身胰岛素抵抗

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The burden of nonalcoholic fatty liver is related to the risk for nonalcoholic steatohepatitis (NASH) and progressive fibrosis, but also to extrahepatic higher morbidity and mortality rates. Hepatic insulin resistance (IR), the hallmark of fatty liver, irrespectively of disease stage, could represent an ideal culprit because it may influence both local liver fibrosis and systemic complications.

机译：非酒精性脂肪肝的负担与非酒精性脂肪性肝炎（NASH）和进行性纤维化的风险有关，也与肝外较高的发病率和死亡率有关。肝胰岛素抵抗（IR）是脂肪肝的标志，无论其处于何种疾病阶段，都可能代表理想的罪魁祸首，因为它可能会影响局部肝纤维化和全身性并发症。

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《Hepatology: Official Journal of the American Association for the Study of Liver Diseases》 |2014年第3期|共2页
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LanthierN.; LeclercqI.A.;
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正文语种 eng
中图分类消化系及腹部疾病;
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机译：肝脏微循环的超微结构影响肝和全身胰岛素活性，并提供与年龄相关的胰岛素抵抗的机制
2. Lycopene ameliorates systemic inflammation-induced synaptic dysfunction via improving insulin resistance and mitochondrial dysfunction in the liver-brain axis [J] . Wang Jia, Zou Qianhui, Suo Yao, Food & Function . 2019,第4期

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3. Glucose and lipid metabolism alterations in liver and adipose tissue pre-dispose p47phox knockout mice to systemic insulin resistance [J] . Kanuri, B.N., Rebello, Free radical research . 2018,第1a12期

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4. Oral Cavity as the Route for Systemic Insulin Delivery: CAPI Trans-mucosal Insulin Delivery System [C] . Tülin Mor??l, Peri Nagappan, Larry Nerenbaum, Annual meeting exposition of the Controlled Release Society . 2005

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5. Cellular & Molecular Mechanisms that Contribute to the Early Development of Skeletal Muscle & Systemic Insulin Resistance [D] . Grice, Brian A. 2019

机译：细胞和分子机制有助于早期发展的骨骼肌和全身胰岛素抵抗力
6. Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age‐related insulin resistance [O] . Mashani Mohamad, Sarah Jayne Mitchell, Lindsay Edward Wu, 2016

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7. Insulin Resistance is Associated With Significant Liver Fibrosis in Chronic Hepatitis C Patients: A Systemic Review and Meta-Analysis [O] . Patel, Suhag, Jinjuvadia, Raxitkumar, Patel, Ravi, 2016

机译：慢性丙型肝炎患者胰岛素抵抗与严重肝纤维化相关：系统评价和荟萃分析

Liver and systemic insulin resistance

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