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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Hepatic Inflammation and Fibrosis: Functional Links and Key Pathways
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Hepatic Inflammation and Fibrosis: Functional Links and Key Pathways

机译：肝炎和纤维化：功能性联系和关键途径

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Inflammation is one of the most characteristic features of chronic liver disease of viral, alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease stages and associated with the development of fibrosis, cirrhosis, and hepatocellular carcinoma. In the past decade, numerous studies have contributed to improved understanding of the links between hepatic inflammation and fibrosis. Here, we review mechanisms that link inflammation with the development of liver fibrosis, focusing on the role of inflammatory mediators in hepatic stellate cell (HSC) activation and HSC survival during fibrogenesis and fibrosis regression. We will summarize the contributions of different inflammatory cells, including hepatic macrophages, T and B lymphocytes, natural killer cells and platelets, as well as key effectors, such as cytokines, chemokines, and damage-associated molecular patterns. Furthermore, we will discuss the relevance of inflammatory signaling pathways for clinical liver disease and for the development of antifibrogenic strategies. (Hepatology 2015;61:1066-1079)
机译：炎症是病毒，酒精，脂肪和自身免疫性疾病引起的慢性肝病的最典型特征之一。炎症通常存在于所有疾病阶段，并与纤维化，肝硬化和肝细胞癌的发展有关。在过去的十年中，许多研究为增进对肝炎症和纤维化之间联系的理解做出了贡献。在这里，我们回顾了将炎症与肝纤维化发展联系起来的机制，重点研究了炎性介质在肝星状细胞（HSC）激活和肝纤维化消退过程中HSC存活中的作用。我们将总结不同炎症细胞的作用，包括肝巨噬细胞，T和B淋巴细胞，自然杀伤细胞和血小板，以及关键效应物，例如细胞因子，趋化因子和与损伤相关的分子模式。此外，我们将讨论炎症信号通路与临床肝病和抗纤维化策略发展的相关性。 （肝病2015; 61：1066-1079）

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