...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Trends in Endocrinology and Metabolism: TEM >Sex with two SOX on: SRY and SOX9 in testis development.
【24h】

Sex with two SOX on: SRY and SOX9 in testis development.

机译：与两个袜子发生性关系：睾丸发育中的DRY和SOX9。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although gonads are not required for development or survival, defects in gonadal development undoubtedly have a profound influence on affected individuals. Recent complementary studies in the fields of cytology, biochemistry and molecular genetics have revealed that normal gonad development involves an exquisitely regulated network of gene expression and protein-protein interactions. The initial event of gonadogenesis, in both males and females, involves the formation of a bipotential primordium. A Y chromosome then activates the male-specific pathway. The demonstration that mutations in the SOX proteins, SRY and SOX9, are responsible for disorders associated with male-to-female sex reversal showed dramatically that SRY and SOX9 have an essential role in male sex differentiation. This was emphasized when it was shown that female mice carrying transgenes that encode these proteins developed as males. SRY and SOX9 proteins have been characterized extensively and aspects of their function and regulation are now known.
机译：尽管性腺不是发育或生存所必需的，但性腺发育的缺陷无疑对受影响的个体有深远的影响。最近在细胞学，生物化学和分子遗传学领域的补充研究表明，正常的性腺发育涉及基因表达和蛋白质-蛋白质相互作用的精确调控的网络。雄性和雌性中性腺发生的最初事件都涉及双电位原基的形成。然后，Y染色体激活男性特异性途径。 SOX蛋白中的突变SRY和SOX9引起了男女性别逆转相关的疾病，这一事实证明，SRY和SOX9在男性性别分化中起着至关重要的作用。当发现携带编码这些蛋白质的转基因的雌性小鼠发育成雄性时，就强调了这一点。 SRY和SOX9蛋白已得到广泛表征，其功能和调节方面现已为人所知。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号