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Genetic Tailors: CTCF and Cohesin Shape the Genome During Evolution

机译:遗传裁缝:CTCF和粘着蛋白塑造进化过程中的基因组。

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摘要

Research into chromosome structure and organization is an old field that has seen some fascinating progress in recent years. Modern molecular methods that can describe the shape of chromosomes have begun to revolutionize our understanding of genome organization and the mechanisms that regulate gene activity. A picture is beginning to emerge of chromatin loops representing a widespread organizing principle of the chromatin fiber and the proteins cohesin and CCCTC-binding factor (CTCF) as key players anchoring such chromatin loops. Here we review our current understanding of the features of CTCF- and cohesin-mediated genome organization and how their evolution may have helped to shape genome structure.
机译:染色体结构和组织的研究是一个古老的领域,近年来已经取得了令人瞩目的进展。可以描述染色体形状的现代分子方法已经开始彻底改变我们对基因组组织和调节基因活性机制的理解。染色质环的图片开始出现,代表了染色质纤维的广泛组织原理,蛋白质粘着蛋白和CCCTC结合因子(CTCF)是锚定此类染色质环的关键参与者。在这里,我们回顾了我们目前对CTCF和粘着蛋白介导的基因组组织特征的了解,以及它们的进化如何帮助塑造基因组结构。

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