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首页> 外文期刊>Human Heredity >Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.
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Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.

机译：对2型糖尿病的遗传易感性与降低的前列腺癌风险相关。

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OBJECTIVE: To examine the collective effects of type 1 (T1D) and type 2 diabetes (T2D) risk alleles on prostate cancer (PCa) risk. METHODS: Using data on 14 and 18 single nucleotide polymorphisms (SNPs) that effect T1D and T2D risk, respectively, we generated risk scores (a 'risk allele count' and a 'genetic relative risk') for both T1D and T2D for 1,171 non-Hispanic white, PSA-screened PCa cases and 1,101 matched controls from the Cancer Genetic Markers of Susceptibility study. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations between the diabetes risk scores and PCa risk. RESULTS: Both T2D risk scores, but neither T1D score, showed an inverse association with PCa (p < 0.01). These associations remained significant after excluding HNF1B SNP rs4430796 (a known PCa risk factor) from the analysis. The highest quartile of the T2D allele count (>20 risk alleles) was associated with reduced PCa risk (OR = 0.77; CI: 0.60-0.99) compared to the lowest category (<17 risk alleles). CONCLUSIONS: These results suggest that individuals with increased genetic susceptibility to T2D have decreased risk for PCa. This association is consistent with the observation that individuals with T2D are at decreased risk for PCa; however, data on T2D status was not available for this analysis.
机译：目的：研究1型（T1D）和2型糖尿病（T2D）风险等位基因对前列腺癌（PCa）风险的总体影响。方法：利用分别影响T1D和T2D风险的14和18个单核苷酸多态性（SNP）数据，我们为1,171个非T1D和T2D产生了风险得分（“风险等位基因计数”和“遗传相对风险”）。 -通过PSA筛查的西班牙裔白色PCa病例和1,101例匹配的对照来自癌症易感性遗传标记研究。 Logistic回归用于估计糖尿病风险评分与PCa风险之间的关联的比值比（OR）和95％置信区间（CI）。结果：两个T2D风险评分，但两个T1D评分均未显示与PCa呈负相关（p <0.01）。从分析中排除HNF1B SNP rs4430796（已知的PCa危险因素）后，这些关联仍然很重要。与最低类别（<17个风险等位基因）相比，T2D等位基因计数最高的四分位数（> 20个风险等位基因）与降低的PCa风险相关（OR = 0.77; CI：0.60-0.99）。结论：这些结果表明，对T2D的遗传易感性增加的人PCa的风险降低。这种关联与以下观点一致：T2D患者的PCa风险降低;但是，T2D状态数据无法用于此分析。

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