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首页> 外文期刊>Human Reproduction >Comparison of follicular fluid IGF-I, IGF-II, IGFBP-3, IGFBP-4 and PAPP-A concentrations and their ratios between GnRH agonist and GnRH antagonist protocols for controlled ovarian stimulation in IVF-embryo transfer patients.
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Comparison of follicular fluid IGF-I, IGF-II, IGFBP-3, IGFBP-4 and PAPP-A concentrations and their ratios between GnRH agonist and GnRH antagonist protocols for controlled ovarian stimulation in IVF-embryo transfer patients.

机译：卵泡液IGF-I，IGF-II，IGFBP-3，IGFBP-4和PAPP-A浓度及其在IVF-胚胎移植患者中控制卵巢刺激的GnRH激动剂和GnRH拮抗剂方案之间的比率的比较。

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BACKGROUND: Insulin-like growth factors (IGF) and their binding proteins (IGFBP) play a major role in the autocrine and paracrine regulation of folliculogenesis. This is the first study that has compared follicular fluid (FF) IGF-I, IGF-II, IGFBP-3, IGFBP-4 and pregnancy-associated plasma protein (PAPP)-A concentrations, and their ratios, to investigate whether there was any difference in the intrafollicular microenvironment between the GnRH agonist (GnRHa) and antagonist (GnRHant) protocols for controlled ovarian stimulation (COS). METHODS: A total of 68 IVF cycles were included in this study; two groups were studied: GnRHa long protocol group (n = 36) and the flexible GnRHant multiple-dose protocol group (n = 32). FF was obtained from dominant follicles during oocyte retrieval and stored at -70 degrees C until assayed. IGF-I, IGF-II and IGFBP-3 concentrations were measured by radioimmunoassay and IGFBP-4 and PAPP-A by enzyme-linked immunosorbent assay. RESULTS: The duration of COS was significantly longer, and total dose of gonadotrophins used, serum estradiol (E(2)) levels on hCG day and the number of oocytes retrieved were significantly higher in the GnRHa long protocol group. The concentrations of FF IGF-II and IGFBP-4 were significantly higher, and the ratio of IGF-I/IGFBP-4 was significantly lower in the GnRHa long protocol group. Serum E(2) levels per mature follicle were not different between the two groups. CONCLUSIONS: Our data may indicate a difference of intrafollicular microenvironment between cycles using GnRHa long protocols and those using GnRHant protocols. However, the difference in microenvironment does not appear to result in a difference in clinical outcome.
机译：背景：胰岛素样生长因子（IGF）及其结合蛋白（IGFBP）在卵泡发生的自分泌和旁分泌调节中起着重要作用。这是第一项比较卵泡液（FF）IGF-I，IGF-II，IGFBP-3，IGFBP-4和妊娠相关血浆蛋白（PAPP）-A浓度及其比率的研究，以调查是否存在GnRH激动剂（GnRHa）和拮抗剂（GnRHant）协议可控制卵巢刺激（COS）的卵泡内微环境的任何差异。方法：本研究共包括68个IVF周期。研究了两组：GnRHa长方案组（n ​​= 36）和灵活的GnRHant多剂量方案组（n ​​= 32）。在卵母细胞取回过程中从优势卵泡中获得FF，并将其储存在-70摄氏度下直至进行分析。通过放射免疫测定法测量IGF-I，IGF-II和IGFBP-3的浓度，通过酶联免疫吸附测定法测量IGFBP-4和PAPP-A的浓度。结果：GnRHa长期方案组的COS持续时间明显更长，所用促性腺激素的总剂量，hCG日的血清雌二醇（E（2））水平和回收的卵母细胞数量均显着更高。在GnRHa长方案组中，FF IGF-II和IGFBP-4的浓度显着较高，而IGF-I / IGFBP-4的比率显着较低。两组之间每个成熟卵泡的血清E（2）水平没有差异。结论：我们的数据可能表明使用GnRHa long方案的周期与使用GnRHant方案的周期之间的卵泡内微环境不同。但是，微环境的差异似乎并未导致临床结果的差异。

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