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首页> 外文期刊>Human and Experimental Toxicology >Comparative cytotoxicity and genotoxicity of cobalt (II, III) oxide, iron (III) oxide, silicon dioxide, and aluminum oxide nanoparticles on human lymphocytes in vitro
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Comparative cytotoxicity and genotoxicity of cobalt (II, III) oxide, iron (III) oxide, silicon dioxide, and aluminum oxide nanoparticles on human lymphocytes in vitro

机译：氧化钴（II，III），氧化铁（III），二氧化硅和氧化铝纳米粒子对人淋巴细胞的体外细胞毒性和遗传毒性

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摘要

Despite the extensive use of nanoparticles (NPs) in various fields, adequate knowledge of human health risk and potential toxicity is still lacking. The human lymphocytes play a major role in the immune system, and it can alter the antioxidant level when exposed to NPs. Identification of the hazardous NPs was done using in vitro toxicity tests and this study mainly focuses on the comparative in vitro cytotoxicity and genotoxicity of four different NPs including cobalt (II, III) oxide (Co3O4), iron (III) oxide (Fe2O3), silicon dioxide (SiO2), and aluminum oxide (Al2O3) on human lymphocytes. The Co3O4 NPs showed decrease in cellular viability and increase in cell membrane damage followed by Fe2O3, SiO2, and Al2O3 NPs in a dose-dependent manner after 24 h of exposure to human lymphocytes. The oxidative stress was evidenced in human lymphocytes by the induction of reactive oxygen species, lipid peroxidation, and depletion of catalase, reduced glutathione, and superoxide dismutase. The Al2O3 NPs showed the least DNA damage when compared with all the other NPs. Chromosomal aberration was observed at 100 mu g/ml when exposed to Co3O4 NPs and Fe2O3 NPs. The alteration in the level of antioxidant caused DNA damage and chromosomal aberration in human lymphocytes.
机译：尽管纳米颗粒（NPs）在各个领域得到了广泛使用，但仍缺乏对人类健康风险和潜在毒性的充分了解。人淋巴细胞在免疫系统中起主要作用，当暴露于NPs时可以改变抗氧化剂的水平。有害NP的鉴定是通过体外毒性试验完成的，本研究主要集中于四种不同NP的体外细胞毒性和遗传毒性的比较，包括氧化钴（II，III）（Co3O4），氧化铁（III）（Fe2O3），人体淋巴细胞上的二氧化硅（SiO2）和氧化铝（Al2O3）。 Co3O4 NPs暴露于人淋巴细胞24小时后，呈剂量依赖性，表现出细胞活力的下降和细胞膜损伤的增加，其次是Fe2O3，SiO2和Al2O3 NPs。通过诱导活性氧，脂质过氧化，过氧化氢酶的消耗，谷胱甘肽减少和超氧化物歧化酶，证明了人类淋巴细胞中的氧化应激。与所有其他NP相比，Al2O3 NP表现出最小的DNA损伤。当暴露于Co3O4 NPs和Fe2O3 NPs时，观察到100μg / ml的染色体畸变。抗氧化剂水平的改变导致人类淋巴细胞的DNA损伤和染色体畸变。

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