Metallation of ligands with biological activity: Synthesis and X-ray characterization of [UO2(PN)(2)(H2O)]Cl-2{PN = vitamin B-6 pyridoxine[2-methyl-3-hydroxy-4,5-bis(hydroxymethyl) pyridine]}

Bonfada T; de Oliveira GM; Back DF; Lang ES

首页> 外文期刊>Zeitschrift fur Anorganische und Allgemeine Chemie >Metallation of ligands with biological activity: Synthesis and X-ray characterization of [UO2(PN)(2)(H2O)]Cl-2{PN = vitamin B-6 pyridoxine[2-methyl-3-hydroxy-4,5-bis(hydroxymethyl) pyridine]}

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Metallation of ligands with biological activity: Synthesis and X-ray characterization of [UO2(PN)(2)(H2O)]Cl-2{PN = vitamin B-6 pyridoxine[2-methyl-3-hydroxy-4,5-bis(hydroxymethyl) pyridine]}

机译：具有生物活性的配体金属化：[UO2（PN）（2）（H2O）] Cl-2 {PN =维生素B-6吡ido醇[2-甲基-3-羟基-4,5-]的合成和X射线表征双（羟甲基）吡啶]}

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Chloridrate of pyridoxine (vitamin 136) reacts with UO2(NO3)(2)center dot 6H(2)O in acetonitril containing triethylamine to give the complex salt [UO2(PN)(2)(H2O)]Cl-2. The structure of the novel compound was analyzed by single crystal X-ray diffraction affording the centrosymmetric triclinic space group P (1) over bar. In [UO2(PN)(2)(H2O)](2+) two zwitterionic pyridoxine molecules complex the uranium atom in a planar manner with a water molecule achieving the coordination of a semi planar pentagon. The two uranyl oxo ligands set the axis of a distorted pentagonal bipyramide. The ability of vitamin B6 pyridoxine to react with UO22+ allowing the chelation of one uranium atom represents a very specific model of assimilation of uranium by living beings. It could also explain the serious damages caused by heavy or radioactive metals like uranium since their complexation "in vivo" by enzymatic systems like pyridoxal phosphate-containing enzymes would lead to a modification of the prosthetic groups of the metalloenzymes with loss of their catalytic activities.

机译：吡ido醇的氯酸盐（维生素136）在含有三乙胺的乙腈中与UO2（NO3）（2）中心点6H（2）O反应，得到复合盐[UO2（PN）（2）（H2O）] Cl-2。通过单晶X射线衍射分析了该新型化合物的结构，得到了棒上的中心对称三斜空间基团P（1）。在[UO2（PN）（2）（H2O）]（2+）中，两个两性离子吡ido醇分子以平面方式将铀原子与水分子络合，从而实现半平面五边形的配位。两个铀酰氧代配体确定了扭曲的五边形双吡咯酰胺的轴。维生素B6吡ido醇与UO22 +的反应允许一个铀原子螯合的能力代表了一种非常特殊的生物同化铀的模型。这也可以解释由重金属或放射性金属（如铀）造成的严重损害，因为它们在体内“被”含吡ido醛磷酸盐的酶等酶系统“络合”会导致金属酶的辅基基团发生修饰而失去催化活性。

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《Zeitschrift fur Anorganische und Allgemeine Chemie》 |2005年第5期|共4页
作者
Bonfada T; de Oliveira GM; Back DF; Lang ES;
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正文语种 eng
中图分类化学;
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uranium; bioinorganic chemistry; uranium assimilation; metallation of biological ligands; CRYSTAL-STRUCTURES; PYRIDOXINE PN; DIOXOURANIUM COMPLEXES; MOLECULAR-STRUCTURES; PYRIDOXAMINE; IONS; CATION;

机译：铀;生物无机化学;铀同化;生物配体的金属化;晶体结构;吡OX醇PN;二氧杂苯胺络合物;分子结构;吡P胺;离子;阳离子;

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1. Metallation of ligands with biological activity: Synthesis and X-ray characterization of [UO2(PN)(2)(H2O)]Cl-2{PN = vitamin B-6 pyridoxine[2-methyl-3-hydroxy-4,5-bis(hydroxymethyl) pyridine]} [J] . Bonfada T, de Oliveira GM, Back DF, Zeitschrift fur Anorganische und Allgemeine Chemie . 2005,第5期

机译：具有生物活性的配体金属化：[UO2（PN）（2）（H2O）] Cl-2 {PN =维生素B-6吡ido醇[2-甲基-3-羟基-4,5-]的合成和X射线表征双（羟甲基）吡啶]}
2. Synthesis, characterization and luminescence properties of lanthanide(III) compounds with 2,6-di(hydroxymethyl)pyridine and the related 2,6-di(hydroxymethyl-d(2))pyridine ligand. X-ray structure of [Sm(2,6-di(hydroxymethyl)pyridine)(3)](NO3)(3) [J] . van Staveren DR., Gorter S., Haasnoot JG., Inorganica Chimica Acta . 2000,第0期

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4. Synthesis, Characterization, and Biological Interaction of Interpenetrating Networks (IPNs) Containing Modified Gelatin and Poly(ethylene glycol) diacrylate [C] . Jeanine A. Burmania, Gabriel J. Martinez-Diaz, Kelly R. Stevens, Annual meeting of the Society For Biomaterials . 2003

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Metallation of ligands with biological activity: Synthesis and X-ray characterization of [UO2(PN)(2)(H2O)]Cl-2{PN = vitamin B-6 pyridoxine[2-methyl-3-hydroxy-4,5-bis(hydroxymethyl) pyridine]}

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