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首页> 外文期刊>Zoological Science >The impact of deafness to the survival of the newborn cells in the brain of juvenile white-rumped munia, Lonchura striata
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The impact of deafness to the survival of the newborn cells in the brain of juvenile white-rumped munia, Lonchura striata

机译：耳聋对少年白腰mu，菱形Lo脑中新生细胞存活的影响

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In white-rumped munia, early auditory experience is critical for normal song development. New neurons are constantly added to the telencephalon in juveniles. We examined the potential role of auditory experience in regulating the developmental changes in the song nuclei and the survival of newborn cells. We chose two special days, postnatal day 23 and 37, at which we deafened the birds through bilateral cochlea removal. All birds were injected with the cell birth marker BrdU two weeks before the lesion surgeries, and then were killed two weeks or one month later. The BrdU-positive cells were distributed throughout the brain, including the high vocal center (HVC), Lobus parolfactorius and the ventricle zone (VZ) in telencephalon, the granular cell layer (GCL) of cerebellum. Moreover, these BrdU-positive cells in the GCL could self-renew. However, the nucleus robustus archistriatalis (RA) did not sprout new neurons in juvenile. In telencephalon except the VZ, 41 percent of BrdU-positive cells were NeuN-positive, too. Deafness had no significant effect on development of HVC and RA, the distribution of new cells, and the survival of new cells in telencephalon. From these data, we propose that auditory deprivation could not affect the survival of new cells of telencephalon within one month. Surprisingly, we found deafness had a complex and dramatic effect on the number of new cells in cerebellum. Deafness at postnatal day 23 could increase the number of new cells in the GCL, while deafness at postnatal day 37 decreased the number.
机译：在白腰状的听觉障碍中，早期听觉经验对于正常的歌曲发展至关重要。新的神经元不断被添加到青少年的末梢脑。我们检查了听觉经验在调节歌核的发育变化和新生细胞存活中的潜在作用。我们选择了两个特殊的日子，即出生后的第23天和第37天，在那一天，我们通过双侧耳蜗切除使家禽耳聋。在病变手术前两周，所有家禽都注射了细胞出生标记BrdU，然后在两周或一个月后杀死。 BrdU阳性细胞分布在整个大脑中，包括高声中枢（HVC），旁脑的Lobus parolfactorius和心室区（VZ），即小脑的颗粒细胞层（GCL）。而且，GCL中的这些BrdU阳性细胞可以自我更新。但是，鲁棒核（istrobusus archistriatalis）（RA）不会在幼年期发芽新的神经元。在除了VZ的端脑中，41％的BrdU阳性细胞也是NeuN阳性的。耳聋对末梢脑的HVC和RA的发展，新细胞的分布以及新细胞的存活没有显着影响。根据这些数据，我们认为听觉剥夺不能在一个月内影响端脑新细胞的存活。令人惊讶的是，我们发现耳聋对小脑中新细胞的数量具有复杂而戏剧性的影响。出生后第23天的失聪可增加GCL中新细胞的数量，而出生后第37天的失聪则减少该数量。

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