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首页> 外文期刊>Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences >Syntheses of Two Co(2) and Ni(2) Complexes with 2-(1H-Imidazolyl-1-methyl)- 1H-benzimidazole and 1,4-Benzenedicarboxylate ligands and their effect on cardiac fibroblasts proliferation
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Syntheses of Two Co(2) and Ni(2) Complexes with 2-(1H-Imidazolyl-1-methyl)- 1H-benzimidazole and 1,4-Benzenedicarboxylate ligands and their effect on cardiac fibroblasts proliferation

机译：2-（1H-咪唑基-1-甲基）-1H-苯并咪唑和1,4-苯二甲酸羧酸酯配体的两个Co（2）和Ni（2）配合物的合成及其对心脏成纤维细胞增殖的影响

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摘要

Two new isostructural complexes based on 2-(1H-imidazolyl-1-methyl)-1H- benzimidazole (imb) and di-anionic 1,4-benzenedicarboxylate (bdic), namely, {[Co(bdic)(imb)~2(H~2O)~2]·2H ~2O}~n (1) and {[Ni(bdic)(imb)~2(H ~2O)~2]·2H~2O}~n (2), have been synthesized and characterized by single-crystal Xray diffraction. Both complexes possess a chain structure with the di-anionic bdic groups bridging the metal ions. The imb ligands coordinate the metal ions in a monodentate mode at two sides of the main chain. These chains are further packed into 3D networks through five kinds of hydrogen bonds. The in vitro effect of 1 and 2 on cultured cardiac fibroblasts (CF) proliferation in the presence or absence of excessive angiotensin 2 (Ang2) have been investigated by a flow cytometric assay. The results have indicated that both complexes have no obvious effect on the cell cycle distribution of CF, but they can suppress the CF proliferation induced by Ang2.
机译：基于2-（1H-咪唑基-1-甲基）-1H-苯并咪唑（imb）和二阴离子1,4-苯二甲酸（bdic）的两个新的同构配合物，{[Co（bdic）（imb）〜2 （H〜2O）〜2]·2H〜2O}〜n（1）和{[Ni（bdic）（imb）〜2（H〜2O）〜2]·2H〜2O}〜n（2）具有通过单晶X射线衍射合成并表征。两种配合物均具有链结构，其中双阴离子bdic基团桥接金属离子。 imb配体在主链的两侧以单齿模式配位金属离子。这些链通过五种氢键进一步包装成3D网络。已经通过流式细胞术研究了在存在或不存在过量血管紧张素2（Ang2）的情况下1和2对培养的心脏成纤维细胞（CF）增殖的体外作用。结果表明，两种复合物对CF的细胞周期分布均无明显影响，但可以抑制Ang2诱导的CF增殖。

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