In vitro cytotoxicity of hydrazones, pyrazoles, pyrazolo-pyrimidines, and pyrazolo-pyridine synthesized from 6-substituted 3-formylchromones

Galarraga Elier; Urdaneta Neudo; Gutierrez Keily J.; Herrera Julio C.

首页> 外文期刊>Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences >In vitro cytotoxicity of hydrazones, pyrazoles, pyrazolo-pyrimidines, and pyrazolo-pyridine synthesized from 6-substituted 3-formylchromones

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In vitro cytotoxicity of hydrazones, pyrazoles, pyrazolo-pyrimidines, and pyrazolo-pyridine synthesized from 6-substituted 3-formylchromones

机译：由6-取代的3-甲酰基色酮合成的hydr，吡唑，吡唑并嘧啶和吡唑并吡啶的体外细胞毒性

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Pyrazoles 4a-f, hydrazones 5a-c and 6a-c, pyrazolo[1,5-a]pyrimidines 7a, b, and pyrazolo[3,4-b]pyridine 8 were prepared in good yields (80-95 %) from the reaction of 6-substituted (H, Me, F) 3-formylchromones 1a-c with N-substituted hydrazines 2a-c and aminopyrazole 3. The cytotoxicity of the synthesized compounds was assessed through the brine shrimp lethality assay. IC50 values were between 80 and 300 mu M. Fluorine substitution decreased IC50 values.

机译：以较高的收率（80-95％）制备了吡唑4a-f，5a-c和6a-c，吡唑并[1,5-a]嘧啶7a，b和吡唑并[3,4-b]吡啶8。 6-取代的（H，Me，F）3-甲酰基色酮1a-c与N-取代的肼2a-c和氨基吡唑3的反应。通过盐水虾致死率测定评估了合成化合物的细胞毒性。 IC50值在80至300μM之间。氟取代降低了IC50值。

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《Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences》 |2015年第5期|共6页
作者
Galarraga Elier; Urdaneta Neudo; Gutierrez Keily J.; Herrera Julio C.;
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正文语种 eng
中图分类化学;
关键词
brine shrimp lethality assay; hydrazones; pyrazolo1; 5-apyrimidines; pyrazolo3; 4-bpyridines;

机译：盐水虾致死率测定;hydr;吡唑并[1;5-a]嘧啶;吡唑并[3;4-b]吡啶;

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1. In vitro cytotoxicity of hydrazones, pyrazoles, pyrazolo-pyrimidines, and pyrazolo-pyridine synthesized from 6-substituted 3-formylchromones [J] . Galarraga Elier, Urdaneta Neudo, Gutierrez Keily J., Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences . 2015,第5期

机译：由6-取代的3-甲酰基色酮合成的hydr，吡唑，吡唑并嘧啶和吡唑并吡啶的体外细胞毒性
2. Synthesis, preliminary cytotoxicity evaluation of new 3-formylchromone hydrazones and phosphorohydrazone ierivatives of coumarin and chromone [J] . A. Lazarenkow, J. Nawrot-Modranka, E. Brzeziiiska, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2012,第8期

机译：香豆素和色酮的新型3-甲酰基色酮和磷hydr衍生物的合成，初步细胞毒性评估
3. Antileishmanial and Antitrypanosomal Activity of Synthesized Hydrazones, Pyrazoles, Pyrazolo[1,5-a]-Pyrimidines and Pyrazolo[3,4-b]- Pyridine [J] . Katherine Figarella, Sabrina Marsiccobetre, Ivan Galindo-Castro, Current bioactive compounds . 2018,第3期

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4. Synthesis and Insecticidal Activities of Novel Pyrazole Amides Containing Hydrazone Substructures [C] . Jian Wu, Baoan Song, Deyu Hu, Proceedings of 4th international symposium on pesticides and environmental safety amp; 5th pan Pacific confernce on pesticide science amp; 8th international workshop on crop protection chemistry and regulatory harmonization . 2012

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5. Development of in vitro toxicity assays with a rainbow trout gill cell line and their use in determining the cytotoxicity and photocytotoxicity of polycyclic aromatic hydrocarbons individually and in a complex mixture [D] . Schirmer, Kristin 1997

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6. Cytotoxic Effects of Newly Synthesized Heterocyclic Candidates Containing Nicotinonitrile and Pyrazole Moieties on Hepatocellular and Cervical Carcinomas [O] . Amira A. El-Sayed, Abd El-Galil E. Amr, Ahmed K. EL-Ziaty, 2019

机译：新合成的包含烟腈和吡唑部分的杂环候选物对肝细胞和宫颈癌的细胞毒性作用
7. Effect of Microwave Irradiation on the Condensation of 6-Substituted 3-Formylchromones with Some Five-membered Heterocyclic Compounds [O] . Margita Lacova, Renata Gasparova, Dusan Loos, 2013

机译：微波辐射对6-取代3-甲酰基色酮与某些五元杂环化合物缩合反应的影响

In vitro cytotoxicity of hydrazones, pyrazoles, pyrazolo-pyrimidines, and pyrazolo-pyridine synthesized from 6-substituted 3-formylchromones

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