Synthesis and HPLC-Analysis of N-(2-Phenyl-cyclopropyl)-Substituted Chain Elongated Nucleoside Analogues

Rene Csuk; Anja Kern; Kristina Mohr

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Synthesis and HPLC-Analysis of N-(2-Phenyl-cyclopropyl)-Substituted Chain Elongated Nucleoside Analogues

机译：N-（2-苯基-环丙基）-取代的链延长核苷类似物的合成和HPLC分析

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摘要

A novel class of nucleoside analogues containing adenine, uracil, thymine and 5-fluorouracil as the heterocyclic moieties have been prepared from 2-phenylcyclopropane carboxylic acid. These compounds showed weak antitumor activity. The resolution of the racemates on an analytical and semipreparative scale was performed by HPLC using chiral stationary phases.

机译：由2-苯基环丙烷羧酸制备了新型的含有腺嘌呤，尿嘧啶，胸腺嘧啶和5-氟尿嘧啶作为杂环部分的核苷类似物。这些化合物显示出弱的抗肿瘤活性。使用手性固定相通过HPLC进行外消旋物在分析和半制备规模上的拆分。

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《Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences》 |1999年第11期|共6页
作者
Rene Csuk; Anja Kern; Kristina Mohr;
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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
nucleoside analogues; HPLC;

机译：核苷类似物;HPLC;

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1. Synthesis and HPLC-Analysis of N-(2-Phenyl-cyclopropyl)-Substituted Chain Elongated Nucleoside Analogues [J] . Rene Csuk, Anja Kern, Kristina Mohr Zeitschrift fur Naturforschung, B. A Journal of Chemical Sciences . 1999,第11期

机译：N-（2-苯基-环丙基）-取代的链延长核苷类似物的合成和HPLC分析
2. Synthesis and Opioid Activity of Side-Chain-to-Side-Chain Cyclic Dynorphin A-(1-11) Amide Analogues Cyclized Between Positions 2 and 5. 1. Substitutions in Position 3 [J] . Balvinder S. Vig, Thomas F. Murray, Jane V. Aldrich Journal of Medicinal Chemistry . 2004,第2期

机译：在位置2和5之间循环的侧链至侧链环状强啡肽A-（1-11）酰胺类似物的合成和阿片类药物活性。1.在位置3取代
3. Synthesis and anticonvulsant evaluation of 2-(substituted benzylidene/ethylidene)-N-(substituted phenyl)hydrazine carboxamide analogues [J] . Mohamed Jawed Ahsan, Habibullah Khalilullah, Sabina Yasmin, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2013,第6期

机译：2-（取代的亚苄基/亚乙基）-N-（取代的苯基）肼羧酰胺类似物的合成和抗惊厥性评价
4. Synthesis of fluorescent nucleoside analogues and their applicationas dual probes for the non-canonical DNA structures [C] . Wen Ann Wee, Jihye Yum, ShingoHirashima 日本化学会春季年会 . 2020

机译：非规范DNA结构的荧光核苷类似物的合成及其适用性双探针
5. Palladium catalyzed synthesis of nucleosides: The total syntheses of adenosine and uridine synthesis of important nucleoside Q analogues. [D] . Sorum, Mark Todd. 2006

机译：钯催化的核苷合成：重要的核苷Q类似物的腺苷和尿苷合成的总合成。
6. Design synthesis and therapeutic potential of 3-(2-(1H-benzodimidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamide analogues [O] . Sumit Tahlan, Kalavathy Ramasamy, Siong Meng Lim, 2018

机译：3-（2-（1H-苯并d咪唑-2-基硫基）乙酰胺基）-N-（取代苯基）苯甲酰胺类似物的设计合成和治疗潜力
7. Synthesis and Characterization of Some New Nucleoside Analogues from Substituted Benzimidazole via 1,3-Dipolar cycloaddition [O] . Baghdad Science Journal 2016

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8. Synthesis of Nucleoside Analogues with Potential Antiviral Activity against Negative Strand RNA Virus Targets. [R] . Walker, R. T. 1989

机译：具有抗负链RNa病毒靶标的潜在抗病毒活性的核苷类似物的合成。

Synthesis and HPLC-Analysis of N-(2-Phenyl-cyclopropyl)-Substituted Chain Elongated Nucleoside Analogues

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