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HPV antibody levels and clinical efficacy following administration of a prophylactic quadrivalent HPV vaccine

机译：预防性四价HPV疫苗接种后HPV抗体水平和临床疗效

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The efficacy of the quadrivalent Human Papillomavirus (HPV) vaccine is thought to be mediated by humoral immunity. We evaluated the correlation between quadrivalent HPV vaccine-induced serum anti-HPV responses and efficacy. 17,622 women were vaccinated at day 1, and months 2 and 6. At day 1 and at 6-12 months intervals for up to 48 months, subjects underwent Papanicolaou and genital HPV testing. No immune correlate of protection could be found due to low number of cases. Although 40% of vaccine subjects were anti-HPV 18 seronegative at end-of-study, efficacy against HPV 18-related disease remained high (98.4%; 95% CI: 90.5-100.0) despite high attack rates in the placebo group. These results suggest vaccine-induced protection via immune memory, or lower than detectable HPV 18 antibody titers.
机译：人们认为四价人乳头瘤病毒（HPV）疫苗的功效是由体液免疫介导的。我们评估了四价HPV疫苗诱导的血清抗HPV反应与疗效之间的相关性。在第1天，第2和第6个月为17,622例妇女接种了疫苗。在第1天和6-12个月的间隔内（长达48个月），受试者接受了Papanicolaou和生殖器HPV测试。由于病例数少，未发现保护免疫相关因子。尽管有40％的疫苗受试者在研究结束时抗HPV 18血清阴性，但是尽管安慰剂组的发作率很高，但针对HPV 18相关疾病的疗效仍然很高（98.4％; 95％CI：90.5-100.0）。这些结果表明疫苗通过免疫记忆诱导的保护作用，或低于可检测的HPV 18抗体效价。

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