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Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males

机译：四价HPV疫苗对男性疫苗和非疫苗HPV类型相关疾病的抵抗力

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摘要

A small number of HPV types are related to a majority of HPV-related neoplastic lesions in humans. High-risk types such as HPV 16 and 18 are most often implicated, although other oncogenic and non-oncogenic HPV types can cause disease in men. The efficacy of the quadrivalent HPV vaccine (qHPV) against external genital lesions and intra-anal disease related to HPV in men has been demonstrated. This report examines the vaccine's efficacy against disease due to 10 additional non-vaccine HPV types, as well as efficacy regardless of HPV detection. The data presented suggest that vaccinating males against HPV 6, 11, 16 and 18 protects them against most vaccine HPV-type related anogenital disease. However, significant efficacy against disease due to non-vaccine HPV types was not seen. In addition, the data do not provide any evidence that vaccination with qHPV vaccine will increase the likelihood of disease caused by non-vaccine types in the short term
机译：少数人乳头瘤病毒类型与人类中大多数人乳头瘤病毒相关的肿瘤性病变有关。尽管其他致癌和非致癌HPV类型可能导致男性患病，但最常见的是高危类型，例如HPV 16和18。已证明四价HPV疫苗（qHPV）对男性的外部生殖器病变和与HPV有关的肛门内疾病的功效。该报告检查了疫苗对由于另外10种非疫苗HPV类型引起的疾病的功效，以及与HPV检测无关的功效。所提供的数据表明，对男性接种HPV 6、11、16和18疫苗可以保护他们免受大多数与HPV型疫苗相关的生殖器疾病的侵害。但是，未观察到针对非疫苗型HPV类型的疾病的显着疗效。此外，该数据没有提供任何证据表明在短期内用qHPV疫苗接种会增加由非疫苗类型引起的疾病的可能性

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