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Microparticles in MF59, a potent adjuvant combination for a recombinantprotein vaccine against HIV-1

机译：MF59中的微粒，一种针对HIV-1的重组蛋白疫苗的有效佐剂组合

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摘要

Novel adjuvant formulations involving PLG microparticles with entrapped recombinant protein antigens (env gp120 and p24 gag) from human immunodeficiency virus type-1 (HIV-1), dispersed in the emulsion adjuvant MF59 were evaluated as potential HIV-1 vaccine candidates in mice and baboons. In mice, the adjuvant combination induced significantly enhanced antibody responses in comparison to either adjuvant used alone. In addition, the polylactide co-glycolide polymer (PLG) microparticles and MF59 combination induced CTL activity against HIV-1 p24 gag. In baboons, the adjuvant combination induced significantly enhanced antibody titers after a single dose of gp120, but the responses were comparable to gp120 in MF59 alone after boosting. Both MF59 + gp120 alone and PLG/gp120 in MF59 induced neutralizing antibodies against a T cell line-adapted (TCLA) strain and a primary isolate of HIV-1. In contrast to the observations with gp120, immunization in baboons with PLG/p24 in MF59 induced significantly enhanced antibody responses after boosting, in comparison to immunization with MF59 alone + p24.
机译：包含PLG微粒的新型佐剂制剂被分散在乳剂佐剂MF59中，该佐剂包含来自人类免疫缺陷病毒1型（HIV-1）的捕获的重组蛋白抗原（env gp120和p24 gag），被评估为在小鼠和狒狒中可能的HIV-1候选疫苗。与单独使用的任一佐剂相比，佐剂组合在小鼠中诱导的抗体反应显着增强。此外，聚丙交酯乙交酯聚合物（PLG）微粒和MF59组合诱导了针对HIV-1 p24 gag的CTL活性。在狒狒中，佐剂组合在单剂gp120后诱导明显提高的抗体效价，但加强后的反应与单独MF59中的gp120相当。单独的MF59 + gp120和MF59中的PLG / gp120均可诱导针对T细胞系适应性（TCLA）菌株和HIV-1主要分离株的中和抗体。与用gp120观察到的结果相反，与单独用MF59 + p24免疫相比，在MF59中用PLG / p24在狒狒中免疫可诱导增强后的抗体应答。

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