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首页> 外文期刊>Vaccine >Prevalence of human papillomavirus types in cervical and oral cancers in central India
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Prevalence of human papillomavirus types in cervical and oral cancers in central India

机译：印度中部宫颈癌和口腔癌中人类乳头瘤病毒类型的患病率

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Cervical cancer that is associated with high-risk human papillomaviruses (HPV) is the most common malignancy in Indian women. Therefore, the establishment of a prevention program is urgently required considering both vaccination and screening. However, relatively little is known about the prevalence of the different HPV types in cervical cancers in different regions of India, particularly central India. In this study, we have determined the HPV type distribution in 180 cervical cancers of women from Sevagram, a rural area from central India. In addition, we have analyzed other epithelial cancers that are known to be in part associated with high-risk HPV infection, i.e. oral (n=65), vulva and vagina (n=7) and penis (n=7). Approximately 93% of cervical cancers were positive for one or more of the high-risk HPV types. HPV16 was the predominant type being present in 81.7% of the cases. The remaining most predominant high-risk HPV types were: 18, 31, 35, 45, 56 and 59. Oral and vulva/vagina cancers were exclusively associated with HPV16, 27.7% and 70%, respectively. None of penile cancers was found positive for any of the high-risk HPV types. These data show that HPV16 vaccination in this geographical region will have considerable impact on the prevention of cervical and other epithelial cancers.
机译：与高危人类乳头瘤病毒（HPV）相关的宫颈癌是印度女性中最常见的恶性肿瘤。因此，迫切需要同时考虑疫苗接种和筛查的预防方案的建立。但是，关于不同HPV类型在印度不同地区（尤其是印度中部）的宫颈癌中的患病率知之甚少。在这项研究中，我们确定了来自印度中部农村地区Sevagram的180例宫颈癌妇女的HPV类型分布。此外，我们还分析了其他与高危HPV感染部分相关的其他上皮癌，即口腔（n = 65），外阴和阴道（n = 7）和阴茎（n = 7）。大约93％的宫颈癌对一种或多种高危HPV类型呈阳性。 HPV16是主要类型，占81.7％。其余最主要的高危HPV类型为：18、31、35、45、56和59。口腔癌和外阴/阴道癌分别与HPV16有关，分别为27.7％和70％。没有发现任何高危型HPV阳性的阴茎癌。这些数据表明，在该地理区域进行的HPV16疫苗接种将对预防宫颈癌和其他上皮癌产生相当大的影响。

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