Long-term humoral and cell-mediated immunity after acellular pertussis vaccination compares favourably with whole-cell vaccines 6 years after booster vaccination in the second year of life

Guiso N; Njamkepo E; Vie le Sage F; Zepp F; Meyer CU; Abitbol V; Clyti N; Chevallier S

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Long-term humoral and cell-mediated immunity after acellular pertussis vaccination compares favourably with whole-cell vaccines 6 years after booster vaccination in the second year of life

机译：无细胞百日咳疫苗接种后的长期体液免疫和细胞介导的免疫优于生命第二年加强疫苗接种后6年的全细胞疫苗

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Humoral and cell-mediated immune responses (CMI) were evaluated in subjects 3 and 6 years after primary and booster vaccination with either three-component acellular (Pa) or whole-cell (Pw) vaccines. Low anti-pertussis toxin (PT) antibody levels confirmed the absence of pertussis disease, consistent with ongoing protection. Anti-pertactin (PRN) antibodies, remained at higher levels in Pa-vaccinated subjects. At year 6, CMI responses continued to be present and were higher in Pa-vaccinated than Pw-vaccinated subjects. Long-term protection with Pa vaccines can be expected to be at least as good as that provided by efficacious Pw vaccines.

机译：在接种三组分无细胞疫苗或全细胞疫苗后的3年和6年，对受试者的体液和细胞介导的免疫反应（CMI）进行了评估。抗百日咳毒素（PT）抗体水平低证实没有百日咳疾病，与持续的保护措施一致。抗泛素（PRN）抗体在Pa疫苗接种的受试者中保持较高水平。在第6年，CMI应答继续存在，接受Pa疫苗接种的受试者比接受Pw疫苗接种的受试者更高。预计Pa疫苗的长期保护至少与有效Pw疫苗所提供的保护一样好。

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《Vaccine》 |2007年第8期|共8页
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Guiso N; Njamkepo E; Vie le Sage F; Zepp F; Meyer CU; Abitbol V; Clyti N; Chevallier S;
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中图分类卫生标准、卫生检查、医药管理;
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1. Long-term humoral and cell-mediated immunity after acellular pertussis vaccination compares favourably with whole-cell vaccines 6 years after booster vaccination in the second year of life [J] . Guiso N, Njamkepo E, Vie le Sage F, Vaccine . 2007,第8期

机译：无细胞百日咳疫苗接种后的长期体液免疫和细胞介导的免疫优于生命第二年加强疫苗接种后6年的全细胞疫苗
2. Persistence of antibodies at 5-6 years of age for children who had received a primary series vaccination with a pentavalent whole-cell pertussis vaccine and a first booster with a pentavalent acellular pertussis vaccine: immunogenicity and tolerance [J] . Langue J, Matisse N, Pacoret P, Vaccine . 2004,第11a12期

机译：接受五价全细胞百日咳百日咳疫苗的初次系列接种和五价脱细胞百日咳疫苗的首次加强免疫的儿童在5-6岁时的抗体持久性：免疫原性和耐受性
3. Pertussis specific cell-mediated immune responses ten years after acellular pertussis booster vaccination in young adults [J] . Vaccine . 2016,第3期

机译：百日咳特异性细胞介导的免疫应答在年轻成年人中的无细胞百日咳疫苗接种后十年
4. Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus,Acellular Pertussis, Inactivated Poliovirus,and Haemophilus Influenzae Type b [C] . Yuelian Sun, Jakob Christensen, Anders Hviid, Second joint biostatistics symposium (2012) . 2012

机译：接种白喉，破伤风，无细胞百日咳，脊髓灰质炎灭活病毒和b型流感嗜血杆菌疫苗后出现高热惊厥和癫痫的风险
5. The requirement of Toll-like receptor signaling in the induction of humoral and cell-mediated immune responses to the orally administered DukoralRTM vaccine. [D] . Sirskyj, Danylo. 2013

机译：Toll样受体信号转导对口服DukoralRTM疫苗的体液和细胞介导的免疫反应的诱导要求。
6. Differential T- and B-Cell Responses to Pertussis in Acellular Vaccine-Primed versus Whole-Cell Vaccine-Primed Children 2 Years after Preschool Acellular Booster Vaccination [O] . Rose-Minke Schure, Lotte H. Hendrikx, Lia G. H. de Rond, 2013

机译：学龄前的无细胞加强免疫后2年无细胞疫苗为主的儿童和全细胞疫苗为主的儿童对百日咳的差异性T细胞和B细胞反应
7. Differential T- and B-Cell Responses to Pertussis in Acellular Vaccine-Primed versus Whole-Cell Vaccine-Primed Children 2 Years after Preschool Acellular Booster Vaccination [O] . Schure, Rose-Minke, Hendrikx, Lotte H., de Rond, Lia G. H., 2013

机译：学龄前的无细胞加强免疫后2年，无细胞疫苗为主的儿童和全细胞疫苗为主的儿童对百日咳的差异性T细胞和B细胞反应
8. Cell-Mediated and Humoral Immune Responses Induced by Scarification Vaccination of Human Volunteers with a New Lot of the Live Vaccine Strain of 'Francisella tularensis'. [R] . Waag, D. M., Galloway, A., Sandstrom, G., 1992

机译：新一代'土拉弗朗西斯菌'活疫苗株人类志愿者瘢痕接种诱导细胞介导和体液免疫应答。

Long-term humoral and cell-mediated immunity after acellular pertussis vaccination compares favourably with whole-cell vaccines 6 years after booster vaccination in the second year of life

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