Randomized trial of the quantitative and functional antibody responses to a 7-valent pneumococcal conjugate vaccine and/or 23-valent polysaccharide vaccine among HIV-infected adults

Feikin DR; Elie CM; Goetz MB; Lennox JL; Carlone GM; Romero-Steiner

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Randomized trial of the quantitative and functional antibody responses to a 7-valent pneumococcal conjugate vaccine and/or 23-valent polysaccharide vaccine among HIV-infected adults

机译：在HIV感染的成年人中对7价肺炎球菌结合疫苗和/或23价多糖疫苗进行定量和功能性抗体反应的随机试验

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In a double-blinded, randomized trial, human immunodeficiency virus (HIV)-infected adults with greater than or equal to 200 CD4 cells/mul received placebo (PL), 7-valent conjugate. or 23-valent pneumococcal polysaccharide (PS) vaccine in one of the following two-dose combinations given 8 weeks apart: conjugate-conjugate, conjugate-polysaccharide. placebo-polysaccharide, placebo-placebo. A total of 67 persons completed the study. Neither significant increases in HIV viral load nor severe adverse reactions occurred in any group. After controlling for confounders. when compared with persons receiving placebo-polysaccharide, persons receiving conjugate-conjugate and conjugate-polysaccharide had higher antibody concentrations (serotypes 4. 6B, 9V and serotype 23F respectively) and opsonophagocytic titers (functional antibody assay, serotypes 9V, 23F and serotypes 4, 6B, 9V. respectively) after the second dose (P < 0.05). The second dose with either conjugate or polysaccharide following the first conjugate dose, however, produced no further increase in immune responses.

机译：在一项双盲，随机试验中，人类免疫缺陷病毒（HIV）感染的成人中CD4细胞/ mul大于或等于200的成年人接受了安慰剂（PL）7价偶联物。或间隔23周的以下两种剂量组合之一的23价肺炎球菌多糖（PS）疫苗：缀合物-缀合物，缀合物-多糖。安慰剂-多糖，安慰剂-安慰剂。共有67人完成了研究。在任何一组中，HIV病毒载量均未显着增加，也未发生严重的不良反应。后为混杂因素控制。与接受安慰剂-多糖的人相比，接受缀合物-缀合物和缀合物-多糖的人具有更高的抗体浓度（分别为4. 6B，9V和23F血清型）和调理吞噬滴度（功能性抗体检测，9V，23F血清型和4，第二剂之后分别为6B，9V）（P ＜0.05）。然而，在第一剂量之后，第二剂量的结合物或多糖均未产生免疫应答的进一步增加。

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《Vaccine》 |2001年第4期|共9页
作者
Feikin DR; Elie CM; Goetz MB; Lennox JL; Carlone GM; Romero-Steiner;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Pneumococcal disease; Conjugate vaccines; Hiv; Human-immunodeficiency-virus; Streptococcus-pneumoniae; Glycoprotein; conjugate; Disease; Children; Assay;

机译：肺炎球菌病;结合疫苗;艾滋病毒;人免疫缺陷病毒;肺炎链球菌;糖蛋白;结合物;疾病;儿童;试验;

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1. Randomized trial of the quantitative and functional antibody responses to a 7-valent pneumococcal conjugate vaccine and/or 23-valent polysaccharide vaccine among HIV-infected adults [J] . Feikin DR, Elie CM, Goetz MB, Vaccine . 2001,第3a4期

机译：在HIV感染的成年人中对7价肺炎球菌结合疫苗和/或23价多糖疫苗进行定量和功能性抗体反应的随机试验
2. Revaccination with 7-valent pneumococcal conjugate vaccine elicits better serologic response than 23-valent pneumococcal polysaccharide vaccine in HIV-infected adult patients who have undergone primary vaccination with 23-valent pneumococcal polysaccharide vaccine in the era of combination antiretroviral therapy [J] . Lu Ching-Lan, Chang Sui-Yuan, Chuang Yu-Chung, Vaccine . 2014,第9期

机译：在联合抗逆转录病毒疗法时代已接受23价肺炎球菌多糖疫苗的初次疫苗接种的HIV感染成年患者中，对7价肺炎球菌共轭疫苗的重新接种引起的血清学反应优于23价肺炎球菌多糖疫苗。
3. Serologic response to primary vaccination with 7-valent pneumococcal conjugate vaccine is better than with 23-valent pneumococcal polysaccharide vaccine in HIV-infected patients in the era of combination antiretroviral therapy [J] . LuC.-L., HungC.-C., ChuangY.-C., Human vaccines & immunotherapeutics. . 2013,第2期

机译：在抗逆转录病毒联合治疗时代，HIV感染患者对7价肺炎球菌结合疫苗的初次接种血清反应优于23价肺炎球菌多糖疫苗
4. Microbiology of acute otitis media with perforation (AOMwiP) in Aboriginal children living in remote communities-monitoring the impact of 7-valent pneumococcal conjugate vaccine (7vPCV) [C] . Amanda Leach, Grant MacKenzie, Kim Hare, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：具有穿孔（Aomwip）的急性中耳炎的微生物学，在偏远社区生活在偏远社区中的土着儿童 - 监测7价肺炎球菌缀合物疫苗的影响（7VPCV）
5. Immune responses of pneumococcal polysaccharide and conjugate vaccines in adults: Effect of human immunodeficiency virus infection [D] . Ahmed, Faruque 1995

机译：成人肺炎球菌多糖和结合疫苗的免疫应答：人类免疫缺陷病毒感染的影响
6. Serologic response to primary vaccination with 7-valent pneumococcal conjugate vaccine is better than with 23-valent pneumococcal polysaccharide vaccine in HIV-infected patients in the era of combination antiretroviral therapy [O] . Ching-Lan Lu, Chien-Ching Hung, Yu-Chung Chuang, 2013

机译：在抗逆转录病毒联合治疗时代HIV感染患者对7价肺炎球菌结合疫苗的初次接种血清学反应优于23价肺炎球菌多糖疫苗
7. A randomized clinical trial of the immunogenicity of 7-valent pneumococcal conjugate vaccine compared to 23-valent polysaccharide vaccine in frail, hospitalized elderly [O] . MacIntyre CR, Ridda I, Gao Z, 2014

机译：7价肺炎球菌结合疫苗与23价多糖疫苗相比在脆弱，住院老年人中的免疫原性随机临床试验

Randomized trial of the quantitative and functional antibody responses to a 7-valent pneumococcal conjugate vaccine and/or 23-valent polysaccharide vaccine among HIV-infected adults

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