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首页> 外文期刊>Vaccine >Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge
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Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge

机译：表达问号钩端螺旋体LipL32抗原的重组牛分枝杆菌BCG保护仓鼠免受攻击

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摘要

The bacillus Calmette-Guerin (BCG), a live attenuated Mycobacterium bovis strain is considered a promising candidate as a vector system for delivery of foreign antigens to the immune system. The gene coding for the Leptospira interrogans external membrane protein LipL32, a highly immunogenic antigen found in all pathogenic leptospira, was cloned into several mycobacterial vectors for expression in BCG. Hamsters immunized with recombinant BCG (rBCG) expressing LipL32 were protected against mortality (P<=0.05) upon challenge with a lethal inoculum of L. interrogans serovar Copenhageni. Autopsy examination did not reveal macroscopic or histological evidence of disease in rBCG immunized hamsters that survived lethal challenge. The data presented here further enhance the status of LipL32 as a promising candidate antigen for use in the control of leptospirosis, when presented to the immune system by an appropriate delivery system.
机译：减毒活牛分枝杆菌卡介苗（BCG）菌被认为是有前途的候选物，可作为将外源抗原递送至免疫系统的载体系统。编码问号钩端螺旋体外膜蛋白LipL32（一种在所有致病性钩端螺旋体中均发现的高度免疫原性抗原）的基因被克隆到几种分枝杆菌载体中以在BCG中表达。用致死的问号L. interrogans serovar Copenhageni接种后，用表达LipL32的重组BCG（rBCG）免疫的仓鼠可以防止死亡（P <= 0.05）。尸检未显示在致死性攻击中存活的经rBCG免疫的仓鼠中疾病的宏观或组织学证据。当通过适当的递送系统提供给免疫系统时，此处提供的数据进一步增强了LipL32作为有望用于控制钩端螺旋体病的候选抗原的地位。

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