Rabies intradermal post-exposure vaccination of humans using reconstituted and stored vaccine

Kamoltham T; Khawplod P; Wilde H

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Rabies intradermal post-exposure vaccination of humans using reconstituted and stored vaccine

机译：使用重组和储存的疫苗对人进行狂犬病皮内暴露后疫苗接种

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Thailand's northern Petchabun province is endemic for canine rabies. There were 27 reported human rabies deaths between 1989 and 1998. A rabies control plan was formulated in 1997 between medical and veterinary public health officials. It started an intense education pro,gram and an ongoing dog vaccination campaign. Economic constraints and the high cost of biological were the main reasons for inadequate human post-exposure management (PET). It was therefore decided to use the economical Thai Red Cross Intradermal Vaccine Regimen (TRC-ID) throughout the province. The original TRC-ID method is only suitable for clinics that see more than one PET patient daily. TRG-ID was therefore modified by storing the reconstituted vaccine in a refrigerator for the same patient's next two visits. Data on a total of 8157 PET patients were collected. An additional modification of TRG-ID also eliminated the 90 day booster. There were no treatment failures and no human rabies deaths in 1999, 2000 and 2001. The modified TRC-ID method induces adequate levels of neutralizing antibodies, protects humans bitten by rabid dogs and results in significant savings in vaccine and travel costs.

机译：泰国北部的碧差汶府是犬狂犬病的地方病。在1989年至1998年之间报告了27例人类狂犬病死亡。1997年，医学和兽医公共卫生官员之间制定了狂犬病控制计划。它开始了严格的教育计划和持续的狗疫苗接种运动。经济限制和高昂的生物成本是人体暴露后管理（PET）不足的主要原因。因此，决定在全省范围内使用经济的泰国红十字会皮内疫苗方案（TRC-ID）。原始的TRC-ID方法仅适用于每天接待多名PET患者的诊所。因此，TRG-ID的修改是将重组疫苗存放在冰箱中，供同一位患者的下两次访问使用。总共收集了8157名PET患者的数据。 TRG-ID的其他修改也消除了90天的增强功能。在1999年，2000年和2001年，没有治疗失败，也没有人类狂犬病死亡。改良的TRC-ID方法可诱导足够水平的中和抗体，保护被狂犬病犬咬伤的人类，并显着节省疫苗和旅行费用。

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《Vaccine》 |2002年第28期|共5页
作者
Kamoltham T; Khawplod P; Wilde H;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Rabies; Intradermal vaccination; Storing of rabies vaccine; Postexposure;

机译：狂犬病;皮内疫苗接种;狂犬病疫苗的存储;暴露后;

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1. Rabies intradermal post-exposure vaccination of humans using reconstituted and stored vaccine [J] . Kamoltham T, Khawplod P, Wilde H Vaccine . 2002,第27a28期

机译：使用重组和储存的疫苗对人进行狂犬病皮内暴露后疫苗接种
2. Rabies post-exposure prophylaxis vaccination with purified chick embryo cell vaccine (PCECV) and purified vero cell rabies vaccine (PVRV) in a four-site intradermal schedule (4-0-2-0-1-1): An immunogenic, cost-effective and practical regimen [J] . Ambrozaitis A, Laiskonis A, Balciuniene L, Vaccine . 2006,第19期

机译：狂犬病暴发后预防性接种疫苗的四点皮内时间表（4-0-2-0-1-1）：采用纯化的鸡胚细胞疫苗（PCECV）和纯化的Vero细胞狂犬病疫苗（PVRV）：有效和实用的方案
3. Intradermal post-exposure rabies vaccination with purified Vero cell rabies vaccine: Comparison of a one-week, 4-site regimen versus updated Thai Red Cross regimen in a randomized non-inferiority trial in the Philippines [J] . Vaccine . 2019,第16期

机译：用纯化的Vero细胞狂犬病疫苗接种皮肤接种狂犬病疫苗：一周的一周，4位方位方案与菲律宾的随机非劣级审判中更新的泰国红十字会的比较
4. PRRS AND ADV: RESULTS OBTAINED FROM THE INTRADERMAL VACCINATION OF GILTS USING THE VACCINES SEPARATELY OR IN COMBINATION [C] . Blanchaert A., Vezzoli F, Pozzi P. Congress ofthe International Pig Veterinary Society . 2008

机译：PRRS和ADV：从单独使用疫苗或组合使用疫苗的胃皮内接种获得的结果
5. Evaluations of parenteral vaccination and alternative oral vaccine delivery systems as potential management strategies for raccoon rabies. [D] . Bigler, Laura L. 1995

机译：评估肠胃外疫苗接种和替代口服疫苗递送系统作为浣熊狂犬病的潜在管理策略。
6. An effective economical intradermal regimen of human diploid cell rabies vaccination for post-exposure treatment. [O] . S Ubol, P Phanuphak 1986

机译：人二倍体细胞狂犬病疫苗接种的有效经济的皮内疗法用于接触后治疗。
7. Intradermal immunization with human diploid cell rabies vaccine: serological and clinical responses of immunized persons to intradermal booster vaccination. [O] . Burridge, M J, Sumner, J W, Baer, G M 1984

机译：人二倍体细胞狂犬病疫苗的皮内免疫：被免疫者对皮内加强免疫的血清学和临床反应。

Rabies intradermal post-exposure vaccination of humans using reconstituted and stored vaccine

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