...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Differential polarization of immune responses by co-administration of antigens with chemokines
【24h】

Differential polarization of immune responses by co-administration of antigens with chemokines

机译：通过抗原与趋化因子的共同施用，免疫应答的差异极化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chemokines are key players in the elicitation of immune response, by selectively attracting subpopulations of immune cells to the site of antigen presentation. Therefore, they are natural candidates for modulating immune responses to antigens qualitatively and quantitatively. We have selected chemokines associated with different arms of the immune response, i.e. RANTES/CCL5, B-lymphocyte chemoattractant/CXCL13, and monocyte chemoattractant protein-1/CCL2, and co-injected DNA expression constructs encoding these chemokines with constructs encoding two HIV antigens, gp120 and gp160, in mice. We subsequently measured markers of both cellular and humoral immune responses, and found that these chemokines qualitatively influenced the outcome of immune responses to both antigens, essentially according to their predicted association to Th profiles. These results are relevant towards the engineering of novel vaccine and immune-based therapies, and point to chemokines as candidate adjuvant and immunomodulatory molecules. Copyright 2004 Elsevier Ltd. All rights reserved.
机译：通过选择性地将免疫细胞的亚群吸引到抗原呈递位点，趋化因子是引发免疫反应的关键因素。因此，它们是定性和定量调节对抗原的免疫应答的天然候选物。我们选择了与免疫应答的不同部分相关的趋化因子，即RANTES / CCL5，B淋巴细胞趋化因子/ CXCL13和单核细胞趋化蛋白-1 / CCL2，并共注射了编码这些趋化因子的DNA表达构建体和编码两种HIV抗原的构建体小鼠中的gp120和gp160。我们随后测量了细胞和体液免疫反应的标记物，发现这些趋化因子定性地影响了对这两种抗原的免疫反应的结果，基本上是根据它们与Th谱的预测关联。这些结果与新型疫苗和基于免疫的疗法的工程设计有关，并指出趋化因子是候选佐剂和免疫调节分子。版权所有2004 ElsevierLtd。保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号