Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination

Mehta Nishaki; Cunningham Coleen K.; Flynn Patricia; Pepe Joyce; Obaro Stephen; Kapogiannis Bill G.; Bethel James; Luzuriaga Katherine; Adolescent Trials Network HIV AIDS

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Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination

机译：接种疫苗后感染HIV的个体中乙型肝炎病毒特异性记忆B细胞的产生受损

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Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination 10 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10 mIU/mlat study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000 mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.

机译：在接种乙肝疫苗后，分别检测了10 15例未感染HIV的青少年和12例感染HIV的青少年，测量了乙肝特异性记忆B细胞（HSMBC）的频率。与未感染艾滋病毒的人相比，在感染艾滋病毒的人中检测到HSMBC的频率明显较低。在研究第28周，检测到HBsAb> 10 mIU / mlat与HSMBC密切相关，并且观察到HBsAb滴度与HSMBC频率之间存在直接相关性。在未感染HIV的个体中，抗体滴度> 1000 mIU / ml与较高的HSMC频率相关。与病毒感染的非HIV感染者或未感染HIV的个体相比，病毒感染的HIV感染者的HSMBC频率较低，记忆B细胞（MBC）增殖减少和B细胞表型改变。

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《Vaccine》 |2010年第21期|共7页
作者
Mehta Nishaki; Cunningham Coleen K.; Flynn Patricia; Pepe Joyce; Obaro Stephen; Kapogiannis Bill G.; Bethel James; Luzuriaga Katherine; Adolescent Trials Network HIV AIDS;
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正文语种 eng
中图分类医学免疫学;
关键词
immune response;

机译：免疫反应;

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专利

1. Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination [J] . Mehta Nishaki, Cunningham Coleen K., Flynn Patricia, Vaccine . 2010,第21期

机译：接种疫苗后感染HIV的个体中乙型肝炎病毒特异性记忆B细胞的产生受损
2. Hepatitis B Vaccination Induced TNF-α- and IL-2-Producing T Cell Responses in HIV? Healthy Individuals Higher than in HIV+ Individuals Who Received the Same Vaccination Regimen [J] . Kriangkrai Chawansuntati, Kanokporn Chaiklang, Romanee Chaiwarith, Clinical & developmental immunology. . 2018,第1期

机译：乙型肝炎疫苗接种诱导在HIV中产生TNF-α-和IL-2产生的T细胞反应？健康的个体高于接受相同疫苗接种方案的艾滋病毒+个人
3. Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8~+ cytotoxic T lymphocyte responses [J] . Christine M. Posavad, David M. Koelle, Mary F. Shaughnessy Proceedings of the National Academy of Sciences of the United States of America . 1997,第19期

机译：感染了单纯疱疹病毒特异性CD8〜+细胞毒性T淋巴细胞反应受损的HIV感染者的严重生殖器疱疹感染
4. Evaluation of CD8~+ T-Cell-Mediated Selection Pressure on Proviral Gag p17 and p24 in Chronically Infected HIV-1~+ Individuals [C] . Westrop S.J., Mandalia S., Nelson M. and Imami N. European Congress of Immunology . 2009

机译：评估CD8〜+ T细胞介导的选择压力在慢性感染HIV-1〜+个体中的荧光GAG P17和P24
5. Patterns of HIV-associated Neurocognitive Impairment among Clade B and Clade E HIV-infected Individuals in Hong Kong. [D] . Chan, Wing Sze Iris. 2010

机译：在香港的进化枝B和进化枝E中，与艾滋病毒相关的神经认知障碍的模式。
6. Impaired Generation of Hepatitis B Virus-specific Memory B Cells in HIV Infected Individuals Following Vaccination [O] . Nishaki Mehta, Coleen K. Cunningham, Patricia Flynn, -1

机译：在接种疫苗后HIV感染个体的乙型肝炎病毒特异性记忆B细胞受损
7. Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination [O] . Mehta, Nishaki, Cunningham, Coleen K., Flynn, Patricia, 2010

机译：疫苗接种后HIV感染者中乙型肝炎病毒特异性记忆B细胞的产生受损

Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination

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