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Long-term memory B-cell responses in recipients of candidate human immunodeficiency virus type 1 vaccines

机译：候选人类免疫缺陷病毒1型疫苗接受者的长期记忆B细胞应答

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摘要

The efficacy and practical application of human immunodeficiency virus type I (HIV-1) vaccines may depend in part on the longevity of the immune responses generated, particularly those in the memory compartment. Candidate vaccines based on the HIV-1 envelope glycoproteins generate binding and neutralizing antibodies in humans but there have been no prior studies on the long-term persistence and recall of those responses. We evaluated six healthy, HIV non-infected adults who had received a combination of recombinant canarypox HIV-1 vaccines boosted by gp120 and who had achieved a high serum titer of neutralizing antibody to HIV-1 MN. These individuals were administered a gp160 boost 4-5 years after their last vaccination. Four volunteers had detectable binding and neutralizing antibodies at the time of boosting and all six volunteers exhibited a recall binding and neutralizing antibody response. The antibodies neutralized multiple T cell line-adapted (TCLA) strains of virus, including the vaccine strain, but not primary isolates. These results demonstrate that memory B-cell responses can last for many years following HIV-1 envelope glycoprotein immunization. In principle, similar long-term memory may be possible with improved immunogens that generate broadly cross-reactive neutralizing antibodies.
机译：人类I型免疫缺陷病毒（HIV-1）疫苗的功效和实际​​应用可能部分取决于所产生的免疫反应的寿命，特别是在记忆仓中。基于HIV-1包膜糖蛋白的候选疫苗可在人体内产生结合抗体和中和抗体，但尚未有关于这些反应的长期持久性和回忆性的先前研究。我们评估了六名健康的，未感染HIV的成年人，他们接受了由gp120增强的重组金丝雀痘HIV-1疫苗的联合治疗，并获得了高血清滴度的HIV-1 MN中和抗体。这些人在上次接种疫苗后4-5年接受了gp160加强免疫。四名志愿者在加强免疫时具有可检测的结合和中和抗体，所有六名志愿者均表现出召回结合和中和抗体反应。抗体中和了多种T细胞系适应（TCLA）病毒株，包括疫苗株，但没有中和分离株。这些结果表明，在HIV-1包膜糖蛋白免疫后，记忆B细胞反应可以持续很多年。原则上，改进的免疫原可以产生广泛的交叉反应中和抗体，因此类似的长期记忆是可能的。

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