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The use of melatonin as a vaccine agent

机译：褪黑激素作为疫苗的用途

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摘要

Molecules with immunomodulatory properties determine the magnitude and quality of immune responses specific for the coadministered antigen. Melatonin is considered a biological-response modifier of the immune system with broad application in veterinary medicine. In seasonally-breeding animals, the indolamine is able to improve reproductive performance. With the purpose of expanding new advantageous roles for melatonin, we investigated the effect of subcutaneous slow-release melatonin implants in the humoral response after a vaccination. We reported here a new feature of melatonin as an adjuvant-like system towards Dichelobacter nodosus (A1 and C serotypes)--the bacterium which cause ovine footrot--the most important cause of lameness in sheep. Antibody titres determined by both agglutination and ELISA techniques were substantially higher and were sustained for a longer duration than non-implanted animals. Remarkably, the effect of melatonin was completely dependent on the presence of aluminium hydroxide. The finding that melatonin enhances a defined immune response in vivo opens new perspectives for the improvement of Th2-biased immune responses by alum adjuvants.
机译：具有免疫调节特性的分子决定了共同给药抗原特异的免疫反应的强度和质量。褪黑素被认为是免疫系统的一种生物反应调节剂，在兽医学中得到广泛应用。在季节性繁殖的动物中，吲哚胺能够改善生殖能力。为了扩大褪黑激素的新的有利作用，我们研究了接种疫苗后皮下缓释褪黑激素植入物在体液反应中的作用。我们在这里报告了褪黑素的新功能，它是针对结节双歧杆菌（A1和C血清型）的佐剂样系统-造成羊足癣的细菌-造成绵羊la行的最重要原因。通过凝集和ELISA技术确定的抗体滴度明显高于未植入动物，并且持续时间更长。值得注意的是，褪黑激素的作用完全取决于氢氧化铝的存在。褪黑激素增强体内确定的免疫反应的发现为明矾佐剂改善Th2偏倚的免疫反应开辟了新的前景。

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