Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route

Montaner AD; De Nichilo A; Elias F; Rodriguez JM; Flo JM; Lopez RA; Zorzopulos J; Frank R

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Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route

机译：神经节苷脂GM1结合肽作为鼻内途径接种抗原的佐剂

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Forty-five GM1-binding peptides were identified using phage-displayed peptides libraries of random peptides. Most have a motif containing a hydrophobic amino acid followed by a serine (S). Based on a GM1-binding assays, two of these GM1-binding peptides (named 15 and 40) were chosen to investigate its immunostimulatory properties when chemically coupled to antigens. Mice intra-nasally (i.n.) vaccinated with some of these complexes developed a better local and systemic antibody response than mice i.n. vaccinated with the respective uncoupled antigens. The efficiency of the complex GM1-binding peptide-antigen strongly depends on the composition and structure of both of the components of the complex.

机译：使用随机肽的噬菌体展示肽库鉴定出45种GM1结合肽。大多数具有包含疏水氨基酸和丝氨酸（S）的基序。基于GM1结合测定，选择了这些GM1结合肽中的两个（分别命名为15和40）来研究其与抗原化学偶联时的免疫刺激特性。经鼻内（i.n.）接种某些复合物的小鼠比小鼠i.n.小鼠具有更好的局部和全身抗体反应。分别接种未偶联的抗原。复合物GM1结合肽-抗原的效率在很大程度上取决于复合物两个组分的组成和结构。

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《Vaccine》 |2006年第11期|共8页
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Montaner AD; De Nichilo A; Elias F; Rodriguez JM; Flo JM; Lopez RA; Zorzopulos J; Frank R;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
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1. Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route [J] . Montaner AD, De Nichilo A, Elias F, Vaccine . 2006,第11期

机译：神经节苷脂GM1结合肽作为鼻内途径接种抗原的佐剂
2. Characterization of the Antigen-Specific CD4 + T Cell Response Induced by Prime-Boost Strategies with CAF01 and CpG Adjuvants Administered by the Intranasal and Subcutaneous Routes [J] . Annalisa Ciabattini, Gennaro Prota, Dennis Christensen, Frontiers in Immunology . 2015,第12期

机译：CAF01和CpG佐剂经鼻内和皮下途径给予初免-加强策略诱导的抗原特异性CD4 + T细胞应答的表征
3. Intranasal administration of peptide antigens of HIV with mucosal adjuvant CpG ODN coentrapped in microparticles enhances the mucosal and systemic immune responses. [J] . Pun PB, Bhat AA, Mohan T, International immunopharmacology . 2009,第4期

机译：将HIV的肽段抗原与粘膜佐剂CpG ODN共同包裹在微粒内进行鼻内给药可增强粘膜和全身免疫反应。
4. Adjuvant Free Peptide Nanofibers Elicit CD8~+ T Cell Responses after Intranasal Administration [C] . Yi Wen, Youhui Si, Anita Chong, Society for Biomaterials annual meeting and exposition . 2017

机译：鼻内给药后无佐剂的肽纳米纤维引起CD8〜+ T细胞应答
5. Development of a Melanoma Therapeutic Vaccine Candidate by the Coencapsulation of Melanoma Antigen Peptides and Toll-like Receptor Ligands as Adjuvants into Polymeric Nanoparticles [D] . Silva, Joana Catarina Mend?o Azeit?o da. 2014

机译：由黑色素瘤抗原肽的COENCAITULATULATULATULATION和Toll样受体配体作为聚合物纳米颗粒的辅助剂的开发
6. Characterization of the Antigen-Specific CD4+ T Cell Response Induced by Prime-Boost Strategies with CAF01 and CpG Adjuvants Administered by the Intranasal and Subcutaneous Routes [O] . Annalisa Ciabattini, Gennaro Prota, Dennis Christensen, 2015

机译：CAF01和CpG佐剂经鼻内和皮下途径给予初免-加强策略诱导的抗原特异性CD4 + T细胞应答的表征
7. Characterization of the antigen-specific CD4+ T cell response induced by prime-boost strategies with CAF01 and CpG adjuvants administered by the intranasal and subcutaneous routes [O] . Annalisa eCiabattini, Gennaro eProta, Dennis eChristensen, 2015

机译：通过鼻内和皮下途径给予CaF01和CpG佐剂的初免 - 加强策略诱导的抗原特异性CD4 + T细胞应答的表征

Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route

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