Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum-derived rhoptry-associated protein 1 peptides

Curtidor H; Ocampo M; Tovar D; Lopez R; Garcia J; Valbuena J; Vera

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Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum-derived rhoptry-associated protein 1 peptides

机译：恶性疟原虫衍生的rhoptry相关蛋白1肽的特异性红细胞结合能力和生物学活性

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Rhoptry-associated protein 1 (RAP1) is a merozoite antigen within Plasmodium falciparum rhoptries as yet having no specific function described for it. Synthetic peptides spanning the RAP1 sequence were tested in erythrocyte binding assays to identify possible RAP1 functional regions. Five high activity binding peptides (HABPs) were identified; 26201, 26202, 26203 and 26204 spanned residues C-461-K-540 within RAP1 Cys region, whilst 26188 (T-201-Y-220) was located in p67 amino terminal. The results showed that peptide binding was saturable, some HABPs inhibited in vitro merozoite invasion and specifically bound to a 72 kDa protein in red blood cell membrane. HABP possible function in merozoite invasion of erythrocytes is also discussed

机译：Rhoptry相关蛋白1（RAP1）是恶性疟原虫rhoptries中的裂殖子抗原，但尚未对其进行描述。在红细胞结合测定中测试了跨越RAP1序列的合成肽，以鉴定可能的RAP1功能区。鉴定了五种高活性结合肽（HABP）。 26201、26202、26203和26204跨越RAP1 Cys区域内的残基C-461-K-540，而26188（T-201-Y-220）位于p67氨基末端。结果表明，肽结合是可饱和的，一些HABPs抑制了体外裂殖子的入侵，并特异性结合了红细胞膜中的72kDa蛋白。还讨论了HABP在裂殖子入侵红细胞中的可能功能

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《Vaccine》 |2004年第8期|共9页
作者
Curtidor H; Ocampo M; Tovar D; Lopez R; Garcia J; Valbuena J; Vera;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Rap1; Peptides; Malaria; Red-blood-cells; Inhibitory monoclonal-antibodies; Merozoite invasion; Antigen; Malaria; Monkeys; Immunogenicity; Sequence; Epitopes; Identification;

机译：Rap1;多肽;疟疾;红细胞;抑制性单克隆抗体;裂殖子入侵;抗原;疟疾;猴子;免疫原性;序列;表位;鉴定;

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专利

1. Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum-derived rhoptry-associated protein 1 peptides [J] . Curtidor H, Ocampo M, Tovar D, Vaccine . 2004,第8期

机译：恶性疟原虫衍生的rhoptry相关蛋白1肽的特异性红细胞结合能力和生物学活性
2. Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum. [J] . P H Jakobsen, L Hviid, T G Theander, Infection and immunity . 1993,第1期

机译：恶性疟原虫的裂殖子蛋白变态反应相关蛋白1和红细胞结合抗原1的特异性T细胞识别。
3. Plasmodium falciparum acid basic repeat antigen (ABRA) peptides:erythrocyte binding and biological activity [J] . Curtidor H, Urquiza M, Suarez JE, Vaccine . 2001,第31期

机译：恶性疟原虫酸基本重复抗原（ABRA）肽：红细胞结合和生物学活性
4. Antibodies to Malaria Peptide Mimics Inhibit Plasmodium falciparum Invasion of Erythrocytes [C] . J.L. Casey, A.M. Coley, J.K. Sabo, International Congress of Parasitology . 2006

机译：疟疾肽模拟物的抗体抑制疟原虫侵袭红细胞的侵袭
5. Understanding Anchoring of Plasmodium Falciparum Exported Proteins to the Erythrocyte Cytoskeleton and Investigating Their Function [D] . Shakya, Bikash. 2017

机译：了解恶性疟原虫输出蛋白锚定到红细胞的细胞骨架和调查其功能。
6. Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptides [O] . Hernando Curtidor, Luis E. Rodríguez, Marisol Ocampo, 2005

机译：恶性疟原虫红细胞结合配体1（EBL-1）衍生肽的比红细胞结合能力和生物学活性
7. Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum erythrocyte binding ligand 1 (EBL-1)-derived peptides [O] . Curtidor, Hernando, Rodríguez, Luis E., Ocampo, Marisol, 2005

机译：恶性疟原虫红细胞结合配体1（EBL-1）衍生肽的比红细胞结合能力和生物学活性
8. Biologically active protein fragments containing specific binding regions of serum albumin or related proteins [R] . 1998

机译：含有血清白蛋白或相关蛋白特异性结合区的生物活性蛋白片段

Specific erythrocyte binding capacity and biological activity of Plasmodium falciparum-derived rhoptry-associated protein 1 peptides

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