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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Minding metals: Tailoring multifunctional chelating agents forneurodegenerative disease
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Minding metals: Tailoring multifunctional chelating agents forneurodegenerative disease

机译：贵金属：针对神经退行性疾病的多功能螯合剂

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摘要

Neurodegenerative diseases like Alzheimer's and Parkinson's disease are associated with elevated levelsof iron, copper, and zinc and consequentially high levels of oxidative stress. Given the multifactorialnature of these diseases, it is becoming evident that the next generation of therapies must have multiplefunctions to combat multiple mechanisms of disease progression. Metal-chelating agents provide onesuch function as an intervention for ameliorating metal-associated damage in degenerative diseases.Targeting chelators to adjust localized metal imbalances in the brain, however, presents significantchallenges. In this perspective, we focus on some noteworthy advances in the area of multifunctionalmetal chelators as potential therapeutic agents for neurodegenerative diseases. In addition to metalchelating ability, these agents also contain features designed to improve their uptake across theblood–brain barrier, increase their selectivity for metals in damage-prone environments, increaseantioxidant capabilities, lower AB peptide aggregation, or inhibit disease-associated enzymes such asmonoamine oxidase and acetylcholinesterase.
机译：像阿尔茨海默氏病和帕金森氏病这样的神经退行性疾病与铁，铜和锌的含量升高以及氧化应激水平升高有关。考虑到这些疾病的多重因素，越来越明显的是，下一代疗法必须具有多种功能来对抗多种疾病进展机制。金属螯合剂可作为一种功能来减轻退行性疾病中金属相关的损害。但是，针对螯合剂以调节大脑中局部金属失衡的目标提出了重大挑战。从这个角度出发，我们将重点放在多功能金属螯合剂作为神经退行性疾病的潜在治疗剂方面的一些显着进展。除具有金属螯合能力外，这些试剂还具有旨在改善其在血脑屏障中的吸收，在易受破坏的环境中提高其对金属的选择性，增强抗氧化能力，降低AB肽聚集或抑制疾病相关酶（如单胺氧化酶）的功能。和乙酰胆碱酯酶。

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