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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >Heterometallic platinum(ii) compounds with β-aminoethylferrocenes: Synthesis, electrochemical behaviour and anticancer activity
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Heterometallic platinum(ii) compounds with β-aminoethylferrocenes: Synthesis, electrochemical behaviour and anticancer activity

机译：具有β-氨基乙基二茂铁的杂金属铂（ii）化合物：合成，电化学行为和抗癌活性

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A new family of heterometallic compounds 3-6 containing ferrocenyl and platinum(ii) centers has been synthesized by reaction of 1-β- aminoethylferrocene (1) and 1,1′-bis(β-aminoethyl)ferrocene (2) with Pt(ii) precursors. Using K _2[PtCl _4] as the Pt(ii) source, the cis-square-planar neutral compounds [Fe{η ~5-C _5H _4(CH _2) _2NH _2} _2PtCl _2] (3) and [{Fe(η ~5-C _5H _4(CH _2) _2NH _2)(η ~5-C _5H _5)} _2PtCl _2] (5) were obtained. Reaction of cis-[PtCl _2(dmso) _2] with 1 and 2 resulted in the displacement of dmso and chloride ligands from the platinum coordination sphere, affording the cationic and neutral compounds [Fe{η ~5- C _5H _4(CH _2) _2NH _2} _2Pt(dmso)Cl]Cl (4) and [Fe(η ~5-C _5H _4(CH _2) _2NH _2)(η ~5-C _5H _5)Pt(dmso)Cl _2] (6). Compounds 3-6 were thoroughly characterized using multinuclear (~1H, ~(13)C, ~(195)Pt) NMR, IR spectroscopy, ESI mass spectrometry and elemental analysis. Single-crystal X-ray analysis of heterometallic 6 confirmed the cis geometry of the molecule and revealed that the platinum atom is held in a perfect square-planar geometry. The electrochemical behaviour of the heterometallic compounds 3-6, which has been examined by cyclic (CV) and square wave (SWV) voltammetries in dichloromethane and dmso solution, is characterized by the reversible one-electron oxidation of the ferrocene moieties. The results of the biological activity studies revealed that the organometallic complex 5 is active against all cell lines with GI _(50) values in the range 1.7-2.3 μM. When compared to the standard anticancer drug cisplatin, heterotrimetallic 5, possessing two aminoethylferrocenyl units coordinated to the Pt(ii) center, showed a greater activity profile in the colon cancer cell line. Cell cycle studies revealed that the new mixed compound exhibits a mechanism of action different to cisplatin.
机译：通过1-β-氨基乙基二茂铁（1）和1,1'-双（β-氨基乙基）二茂铁（2）与Pt（1）反应合成了一个新的含二茂铁基和铂（ii）中心的杂金属化合物3-6族。 ii）前体。使用K _2 [PtCl _4]作为Pt（ii）源，顺式-方形平面中性化合物[Fe {η〜5-C _5H _4（CH _2）_2NH _2} _2PtCl _2]（3）和[{Fe得到（η〜5-C _5H _4（CH _2）_2NH _2）（η〜5-C _5H _5）} _2PtCl _2]（5）。顺式-[PtCl _2（dmso）_2]与1和2的反应导致dmso和氯化物配体从铂配位球中置换，得到阳离子和中性化合物[Fe {η〜5- C _5H _4（CH _2） ）_2NH _2} _2Pt（dmso）Cl] Cl（4）和[Fe（η〜5-C _5H _4（CH _2）_2NH _2）（η〜5-C _5H _5）Pt（dmso）Cl _2]（6 ）。使用多核（〜1H，〜（13）C，〜（195）Pt）NMR，IR光谱，ESI质谱和元素分析对化合物3-6进行了全面表征。异金属6的单晶X射线分析证实了分子的顺式几何结构，并揭示了铂原子保持在理想的方形平面几何结构中。异金属化合物3-6的电化学行为已通过在二氯甲烷和dmso溶液中的循环（CV）和方波（SWV）伏安法进行了研究，其特征在于二茂铁部分可逆的单电子氧化。生物活性研究的结果表明，有机金属配合物5对GI_（50）值在1.7-2.3μM范围内的所有细胞系均具有活性。与标准抗癌药顺铂相比，具有两个与Pt（ii）中心配位的氨基乙基二茂铁基单元的异三金属5在结肠癌细胞系中显示出更大的活性。细胞周期研究表明，新的混合化合物表现出不同于顺铂的作用机理。

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