Interactions of Cu~2+ ions with chicken prion tandem repeats

Pawel Stanczak; Marek Luczkowski; Paulina Juszcziyk; Zbigniew Grzonka; Henryk Kozlowski

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Interactions of Cu~2+ ions with chicken prion tandem repeats

机译：Cu〜2 +离子与鸡肉病毒串联重复序列的相互作用

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The potentiometric and spectroscopic(EPR,UV-Vis,CD)data have shown that the chicken prion hexa-repeat(Ac-His-Asn-Pro-Gly-Tyr-Pro-NH_2)is a very specific ligand for Cu~2+ ions.The His imidazole is an anchoring binding site,then the adjacent amide nitrogen coordinates as a second donor.The presence of Pro at position 3 induces binding of phenolate oxygen as a third donor atom.The tridentate coordination dominates around physiological pH.Similar to human octapeptide fragments,chicken tandem repeats exhibit a cooperative effect in binding Cu~2+ ions,although chicken peptides are much less effective in metal ion coordination.

机译：电位和光谱（EPR，UV-Vis，CD）数据表明，chicken病毒六重复序列（Ac-His-Asn-Pro-Gly-Tyr-Pro-NH_2）是Cu〜2 +的非常特殊的配体His咪唑是一个锚定结合位点，然后相邻的酰胺氮配位为第二个供体.Pro在3位上的存在诱导酚氧作为第三个供体原子的结合。三齿配位在生理pH值附近占主导地位。人的八肽片段，鸡串联重复序列在结合Cu〜2 +离子方面表现出协同作用，尽管鸡肽在金属离子配位方面的作用远不如此。

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《Dalton transactions: An international journal of inorganic chemistry》 |2004年第14期|共6页
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Pawel Stanczak; Marek Luczkowski; Paulina Juszcziyk; Zbigniew Grzonka; Henryk Kozlowski;
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1. Interactions of Cu~2+ ions with chicken prion tandem repeats [J] . Pawel Stanczak, Marek Luczkowski, Paulina Juszcziyk, Dalton transactions: An international journal of inorganic chemistry . 2004,第14期

机译：Cu〜2 +离子与鸡肉病毒串联重复序列的相互作用
2. Copper(Ⅱ) coordination outside the tandem repeat region of an unstructured domain of chicken prion protein [J] . Ewa Gralka, Daniela Valensin, Karolina Gajda, Molecular BioSystems . 2009,第5期

机译：鸡病毒蛋白非结构域串联重复区外的铜（Ⅱ）配位
3. Membrane Interactions and Conformational Preferences of Human and Avian Prion N-Terminal Tandem Repeats: The Role of Copper(II) Ions, pH, and Membrane Mimicking Environments [J] . Giuseppe Di Natale The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical . 2010,第43期

机译：人和禽Pri病毒N末端串联重复的膜相互作用和构象偏好：铜（II）离子，pH和膜模拟环境的作用。
4. QCM-Analyses of the Intermolecular Interaction between Prion Protein N-Terminal Domains Having Increased Number of Octapeptide Repeat [C] . Keiko Sato, Yuji Horiuchi, Ayami Matsushima Japanese peptide symposium . 2011

机译：朊病毒蛋白质N-末端域之间分子间相互作用的QCM分析，其八肽重复数量增加
5. Adsorption and reaction of Pb(2+) and Cu(2+) on pristine and modified oxides in aqueous suspension. [D] . Weesner, Forrest James. 1997

机译：Pb（2+）和Cu（2+）在水悬浮液中的原始氧化物和改性氧化物上的吸附和反应。
6. Electron paramagnetic resonance evidence for binding of Cu(2+) to the C-terminal domain of the murine prion protein. [O] . G M Cereghetti, A Schweiger, R Glockshuber, 2001

机译：电子顺磁共振证据表明Cu（2+）与鼠mu病毒蛋白的C末端域结合。
7. The effect of a membrane-mimicking environment on the interactions of Cu2+ with an amyloidogenic fragment of chicken prion protein [O] . Hecel, Aleksandra, Draghi, Sara, Valensin, Daniela, 2017

机译：膜模拟环境对Cu2 +与鸡朊蛋白淀粉样蛋白片段相互作用的影响

Interactions of Cu~2+ ions with chicken prion tandem repeats

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