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首页> 外文期刊>Dermatologic surgery >Topical 5-aminolevulinic acid with intense pulsed light versus intense pulsed light for photodamage in Chinese patients.
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Topical 5-aminolevulinic acid with intense pulsed light versus intense pulsed light for photodamage in Chinese patients.

机译：在中国患者中，局部5-氨基乙酰丙酸与强脉冲光对比强脉冲光对光损伤。

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BACKGROUND: It has been suggested that the adjunctive use of 5-aminolevulinic acid (ALA) with intense pulsed light (IPL), known as ALA-IPL photodynamic therapy (PDT), increases the benefits of IPL therapy for photoaging. OBJECTIVE: To evaluate the efficacy and safety of ALA-IPL PDT for photoaging in Chinese subjects with Fitzpatrick skin types III and IV. METHOD: This was a prospective, controlled, split-face study with 26 subjects. Subjects received three split-face treatments 4 weeks apart. A blinded investigator assessed the signs of photodamage. Satisfaction was also assessed. RESULT: Twenty-four subjects completed the trial. Better results were achieved for global score, fine lines, and coarse wrinkles on the PDT/IPL treated side than on the IPL-only side at the final visit (50% vs 12.5%p=.005 for global score, 70.8% vs 33.3%p=.009 for fine lines, 50% vs. 12.5%, p=.005 for coarse wrinkles). Phototoxic reactions such as erythema and edema were the primary side effects, as well as an increase in postinflammatory hyperpigmentation. CONCLUSION: ALA-IPL PDT has superior rejuvenation effects over IPL alone in Chinese subjects. Taking reasonable precaution to prevent the postinflammatory hyperpigmentation is the most important point in making ALA-IPL PDT a successful therapy.
机译：背景：已经提出，将5-氨基乙酰丙酸（ALA）与强脉冲光（IPL）一起使用，称为ALA-IPL光动力疗法（PDT），可以增加IPL疗法对光老化的益处。目的：评估ALA-IPL PDT对III型和IV型Fitzpatrick皮肤病患者光老化的有效性和安全性。方法：这是一项前瞻性对照对照研究，涉及26名受试者。受试者相距4周接受了三种劈脸治疗。失明的研究者评估了光损伤的迹象。满意度也进行了评估。结果：24名受试者完成了试验。在最终访视时，PDT / IPL处理侧的整体评分，细纹和粗皱纹的效果要优于仅IPL一侧（整体评分分别为50％vs.12.5％p = .005、70.8％vs 33.3） ％p = .009（细纹），50％vs.12.5％，p = .005（粗纹）。主要的副作用是红斑和水肿等光毒性反应，以及炎症后色素沉着的增加。结论：ALA-IPL PDT在中国受试者中具有比仅IPL更好的复兴效果。采取合理的预防措施以防止炎症后色素沉着是使ALA-IPL PDT成功治疗的最重要要点。

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