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首页> 外文期刊>Dermatologic surgery >Human cadaveric dermal matrix for management of challenging surgical defects on the scalp.
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Human cadaveric dermal matrix for management of challenging surgical defects on the scalp.

机译：人类尸体真皮基质，用于处理头皮上具有挑战性的手术缺陷。

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摘要

BACKGROUND: Biologic scaffolds have shown promise in patients unable to tolerate prolonged surgical closure or extensive wound care, but there has been little research in the field of Mohs micrographic surgery (MMS) on human cadaveric dermis in this capacity. OBJECTIVE: To evaluate the utility of human cadaveric dermis as a means of decreasing operative time, minimizing postoperative wound care, and improving aesthetic outcomes in selected patients with deep surgical defects, including those with exposed bone. METHODS: Fourteen patients (8 men, 6 women) with deep postoperative defects after MMS were treated with a cadaveric dermal allograft as part or all of their postoperative wound management. RESULTS: Allograft placement was well tolerated, with high satisfaction levels relating to minimal postoperative wound care and aesthetic outcome. Significantly shorter operative times were noted in all patients than with primary closure or grafting. CONCLUSION: In patients with significant comorbidities, inability to tolerate extended surgical repairs, or inability to perform extensive wound care, human cadaveric dermal allografts can decrease operative time and minimize wound care complexity while providing an excellent aesthetic outcome in many cases. Shorter healing times than expected were also noted in a number of patients. The authors have indicated no significant interest with commercial supporters.
机译：背景：生物支架在不能耐受长期手术闭合或广泛伤口护理的患者中显示出希望，但是在莫氏显微外科手术（MMS）领域中以这种能力对人尸体真皮进行的研究很少。目的：评估人类尸体真皮在减少深部手术缺损（包括骨暴露者）的手术时间，减少术后伤口护理和改善美学效果方面的实用性。方法：14例MMS术后深部缺损的患者（男8例，女6例）接受尸体真皮同种异体移植治疗，作为部分或全部术后伤口处理方法。结果：同种异体植入物的耐受性良好，满意度高，术后伤口护理和美学效果极低。与初次闭合或移植相比，所有患者的手术时间均明显缩短。结论：在合并症严重，无法忍受延长的外科手术修复或无法进行广泛的伤口护理的患者中，人尸体真皮同种异体移植可减少手术时间并最大程度地减少伤口护理的复杂性，同时在许多情况下可提供出色的美学效果。在许多患者中，还发现愈合时间比预期的要短。作者表示对商业支持者没有太大兴趣。

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