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首页> 外文期刊>Dermatologic surgery >Pulsed dye laser and pulsed dye laser-mediated photodynamic therapy in the treatment of dermatologic disorders
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Pulsed dye laser and pulsed dye laser-mediated photodynamic therapy in the treatment of dermatologic disorders

机译：脉冲染料激光和脉冲染料激光介导的光动力疗法治疗皮肤病

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Background The pulsed dye laser (PDL) is used for treating cutaneous vascular disorders. Recent reports have also shown its effectiveness in conditions of other etiologies, although the precise mechanisms of action are unknown. PDL has also been used in photodynamic therapy (PDT) for many dermatologic conditions. We review the broad array of disorders that can be effectively managed using the PDL. Objectives and Methods A review of the literature on the application of the PDL and PDL-mediated PDT in dermatologic disorders. A literature-based search was performed using PubMed from 1997 to 2010. Search terms included: "pulsed dye laser," "pulsed dye laser photodynamic therapy," and "pulsed dye laser indications." Results The PDL was initially designed for cutaneous vascular disorders. Recent investigations have demonstrated successful results when treating malignant, inflammatory, viral, and collagenous conditions. Side effects, including pain, purpura, edema, and postinflammatory hyperpigmentation, were mild, well tolerated, and transient. Conclusions PDL is accepted as first-line therapy for vascular disorders including port-wine stains, telangiectasias, and hemangiomas. PDL causes selective photothermolysis of dermal vasculature. This mechanism also allows it to be applicable for disorders of other etiologies. Recent studies suggest that the PDL may induce cytokine expression and collagen formation, further increasing its applicability in dermatology.
机译：背景技术脉冲染料激光（PDL）用于治疗皮肤血管疾病。尽管尚不清楚确切的作用机理，但最近的报道也显示了其在其他病因条件下的有效性。 PDL也已用于许多皮肤科疾病的光动力疗法（PDT）。我们回顾了可以使用PDL有效治疗的各种疾病。目的和方法有关PDL和PDL介导的PDT在皮肤病中的应用的文献综述。从1997年至2010年，使用PubMed进行了文献检索。检索词包括：“脉冲染料激光”，“脉冲染料激光光动力疗法”和“脉冲染料激光适应症”。结果PDL最初设计用于皮肤血管疾病。最近的研究表明，在治疗恶性，炎性，病毒性和胶原性疾病时，成功的结果。副作用包括疼痛，紫癜，水肿和发炎后色素沉着，为轻度，耐受性良好和短暂的。结论PDL被认为是血管疾病的一线治疗方法，包括葡萄酒斑，毛细血管扩张和血管瘤。 PDL引起真皮血管的选择性光热解。该机制还使其可用于其他病因疾病。最近的研究表明，PDL可能会诱导细胞因子的表达和胶原蛋白的形成，从而进一步提高其在皮肤病学中的适用性。

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