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首页> 外文期刊>Hormone research in p?diatrics >Health-related quality of life in short children born small for gestational age: Effects of growth hormone treatment and postponement of puberty
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Health-related quality of life in short children born small for gestational age: Effects of growth hormone treatment and postponement of puberty

机译：小于胎龄的矮个儿童的健康相关生活质量：生长激素治疗的影响和青春期的推迟

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Aims: To investigate health-related quality of life (HRQoL) in short children born small for gestational age (SGA) during growth hormone (GH) treatment and additional postponement of puberty by gonadotropin-releasing hormone analogue (GnRHa). Methods: HRQoL was studied longitudinally during 2 years of treatment in 97 short SGA children (mean age 11.6 years at start). The children were divided into three groups: prepubertal GH-treated (prep-GH) children, pubertal GH-treated (pub-GH) children, and pubertal GH-treated children with additional GnRHa treatment (pub-GH/GnRHa). HRQoL was measured by generic (TACQOL) and short stature-specific (TACQOL-S) questionnaires. Results: The TACQOL-S showed that prep-GH children experienced significant HRQoL improvement on the subscales 'contact with adults', 'body image' and 'vitality', and pub-GH/GnRHa children on the subscales 'contact with adults', 'contact with peers' and 'physical abilities'. Parents of prep-GH and pub-GH/GnRHa children reported significant HRQoL improvement on most TACQOL-S scales, whereas HRQoL improvement in pub-GH children reached significance for 'future prospects' only. The HRQoL gain was similar in the three groups, also after correction for confounders. The generic questionnaire TACQOL did not reveal any changes. Conclusions: HRQoL improved in prepubertal and pubertal short SGA children during GH treatment. Additional GnRHa treatment had no adverse effect on the HRQoL gain. Disorder-specific questionnaires were particularly appropriate to evaluate HRQoL in children treated for short stature.
机译：目的：研究生长激素（GH）治疗期间胎龄短（SGA）的矮个儿童的健康相关生活质量（HRQoL），以及促性腺激素释放激素类似物（GnRHa）进一步推迟青春期。方法：对97名SGA矮小儿童（平均年龄11.6岁开始）在治疗2年期间的纵向HRQoL进行了研究。这些孩子分为三组：青春期前用GH治疗的儿童（prep-GH），青春期用GH治疗的儿童（pub-GH）和青春期用GH治疗的儿童（另加GnRHa治疗）（pub-GH / GnRHa）。 HRQoL通过通用（TACQOL）和身材矮小（TACQOL-S）问卷进行测量。结果：TACQOL-S显示，pre-GH儿童在“与成年人接触”，“身体形象”和“生命力”子量表上的HRQoL显着提高，而pub-GH / GnRHa儿童在“与成年人接触”子量表上的HRQoL显着提高， “与同伴接触”和“身体能力”。 pre-GH和pub-GH / GnRHa儿童的父母报告说，在大多数TACQOL-S量表上HRQoL都有显着改善，而pub-GH儿童的HRQoL改善仅对“未来前景”有意义。校正混杂因素后，三组的HRQoL增幅相似。通用调查表TACQOL没有显示任何更改。结论：GH治疗期间，青春期前和青春期短SGA儿童的HRQoL改善。额外的GnRHa治疗对HRQoL的增加没有不利影响。针对疾病的问卷特别适合评估身材矮小儿童的HRQoL。

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